The number of exacerbations during prednisolon tapering were investigated
5-Fluoracil concentration as well. Results Twenty five of 81 patients with AH were treatment dependent (TD). Mean age was 52+18 (M/F:1/24) and 55+13 (M/F:8/48) in TD and GR patients, respectively. Six of 25 TD patients had more than 3 times exacerbations during prednisone tapering. The patients with >3 exacerbations were younger than those with <3 exacerbations (56,6+16 vs 37+15, p:0,02). ALT normalized within 6 months in 16 (69,6%) TD patients and in 46 (88,5%) GR patients (p<0,046). Maintenance dose of prednisolon was higher in TD patients (8,05±4,8 vs 4,98±2,2 mg/day; p. 0,016) as expected. Duration of prednisone treatment was longer in TD patients (44±29 vs 27±22 months; p:0,013). Side effects (29% vs 8,3%) and dose reductions (43% vs 20%) of azathio-prine were more common in TD patients (p<0,05). ALT, AST, GGT, globulin levels were higher in TD patients comparing to GR patients at 6th month of therapy (p<0,05). Anti smooth muscle antibody (ASMA) positivity was more common in TD patients with higher number of exacerbations
(%80 vs %27,8; p:0,056). Liver disease progression was observed in 9 TD (36%) patients and in 8 (14%) GR patients during a median of 27 (6-168) months of follow up (p:0.027). Conclusions. Treatment dependent patients use higher dose of prednisolon with longer duration. Their biochemical remission is achieved later comparing selleck compound to GR patients’. Azathioprine side effects or intolerance are important issues for treatment dependency. As TD patients have more progressive liver disease, other immmuno-supresive drugs such as mycophenolate mofetil or cyclosporine should be tried. Disclosures: Ulus S. Akarca – Advisory Committees or Review Panels: GILEAD, BMS, MSD The following people have nothing to disclose: Berna Gürsel, Fulya Gunsar, Funda Yilmaz, Zeki Karasu, Galip ERsoz “
“Background and Aim: Expression profiling of genes specific to pediatric Crohn’s Disease (CD) patients was performed to elucidate the molecular mechanisms underlying disease cause and pathogenesis at disease
onset. Methods: We used suppressive subtractive hybridization (SSH) and differential screening analysis 上海皓元 to profile the mRNA expression patterns of children with CD and age- and sex-matched controls without inflammatory bowel disease (IBD). Results: Sequence analysis of 1000 clones enriched by SSH identified 75 functionally annotated human genes, represented by 430 clones. The 75 genes have potential involvement in gene networks, such as antigen presentation, inflammation, infection mechanism, connective tissue development, cell cycle and cancer. Twenty-eight genes were previously described in association with CD, while 47 were new genes not previously reported in the context of IBD. Additionally, 29 of the 75 genes have been previously implicated in bacterial and viral infections.