2% in Australia. A low awareness rate in contrast to high prevalence of CKD is MK-8669 order a serious public health problem in Taiwan. Hsu et al. 8 reported an overall awareness rate of CKD of 9.7% in contrast to 6.9% prevalence rate for CKD stage 3–5. Awareness rates for each stage of CKD were 8.0% (stage 3), 25.0% (stage 4) and 71.4% (stage 5). In Wen’s report,13 the overall awareness of CKD stage 1–5 was only 3.5%. Awareness rates for each stage of CKD are 2.66% (stage 1), 2.68% (stage 2), 4.10%

(stage 3), 23.67% (stage 4) and 52.40% (stage 5). Notably, low awareness in contrast to high prevalence of CKD is especially more common in subjects of low socioeconomic and educational status. This fact raises the importance of promoting awareness of CKD through patient education and an intensive screening program. For example, World Kidney Day and a public media campaign have been implemented in Taiwan since 2007. More importantly, continuing medical education is crucially needed for each level of medical physician in all specialties. We must foster the health-care professionals to learn the new concept of CKD definition AZD3965 price and classification4 and to provide the rational care for this rapidly growing population of CKD. Taiwan has the highest incidence and prevalence rate of ESRD based on international comparisons of the USRDS report.11 Based on the

National Dialysis Registry by the Taiwan Society of Nephrology (TSN), Yang et al. reported that from 1990 to 2001 incidence and prevalence rates of ESRD patients increased 2.6 times from 126 to 331/million populations (pmp) and 3.46 times from 382 to 1322/pmp, respectively, from 1990 to 2001.27 Recent data from the Dialysis Registration of the TSN in 2007 reported 48 072 haemodialysis

(HD) and 4465 peritoneal cases, corresponding to a prevalence of 2288/pmp and incidence of 415/pmp, respectively.11 The heavy burden of renal replacement therapy by dialysis was managed by a total of 1081 board-certificated nephrologists, 534 dialysis centres and 14 502 HD machines. Moreover, the domestic renal transplant patients from 1997–2007 were 2054 cases based on the data of the Bureau of National Health Insurance (BNHI). However, it was estimated that another 50% of patients received NADPH-cytochrome-c2 reductase off-shore renal transplantation, mainly from China. There are several possible explanations for the high incidence and prevalence of ESRD in Taiwan. First, a major reason is that the launching of the NHI in 1995 provided free coverage for dialysis therapy without co-payment.28 The universal coverage facilitates the utilizations of renal replacement therapy and further accelerates the inflow of dialysis patients. Second, the better health-care system may improve the survival rate of chronic diseases patients and increase the overall life expectancy. This reason is supported by the evidence that the increased ESRD population consisted of mainly elderly (>65 years) and diabetic patients in Taiwan.