Recently hyperuricemia was reported to be another risk factor for CKD. Although some studies have shown that allopurinol treatment resulted in the improvement of oxidative stress and endothelial dysfunction, it is unclear whether allopurinol has beneficial effects
beyond uric acid lowering. We investigated the independent influence of hyperuricemia on renal function and effect of its amelioration by allopurinol in patients with selleck chemicals BN. Methods: We selected 22 cases of BN diagnosed by renal biopsy at Kitano hospital. Clinical parameters at renal biopsy and decline of renal function were compared between allopurinol group and no allopurinol group. Results: Mean observation period was 3.2 years. Clinical characteristics of 22 patients at renal biopsy were male: 50.0%, age: 58.9 ± 9 years, BMI: 25.9 ± 5 kg/m2, hypertension: 90.9%, diabetes: 13.6%, hyperuricemia: 72.7%, urinary protein: 0.81 ± 1.6 g/day, eGFR: 61.2 ± 24.7 ml/min, and uric acid: 7.10 ± 1.2 mg/dl. Mean change of eGFR of 22 patients was −2.95 ± 4.4 ml/min/year. Uric acid level and change of eGFR were negatively correlated (r = −0.433). When compared between allopurinol group (n = 7) and no allopurinol group (n = 15), there were no difference in
blood pressure (132.0 ± 18.6/78.1 ± 10.7 mmHg vs 132.9 ± 19.0/75.5 ± 14.6 mmHg), urinary protein (0.44 ± 0.5 g/day vs 0.99 ± 2.0 g/day), eGFR (49.3 ± 24.2 ml/min vs 70.1 ± 25.9 ml/min), BMI (24.3 ± 4.2 kg/m2 vs 29.1 ± 5.5 kg/m2), use of ACEI/ARB INK128 (83.3% vs 82.3%), and diabetes (14.2% vs 11.7%). Mean uric acid level during the observation period in allopurinol group and no allopurinol group was 7.3 ± 1.0 mg/dl and 6.9 ± 0.9 mg/dl, respectively, and there was no significant difference. Mean changes of eGFR in allopurinol group (−3.42 ± 4.7 ml/min/year) and no allopurinol group (−2.73 ml/min/year) were not significantly different. Conclusion: Hyperuricemia was a risk factor for decline of eGFR in benign nephrosclerosis. Additional effect of allopurinol more than reducing uric
acid level was not observed. YANAGISAWA NAOKI1,2, HARA MASAKI1,2, ANDO MINORU1,2, AJISAWA ATSUSHI2, TSUCHIYA KEN1, NITTA however KOSAKU1 1Department IV of Internal Medicine, Tokyo Women’s Medical University; 2Division of Infectious Diseases and Nephrology, Department of Medicine, Tokyo Metropolitan Komagome Hospital Introduction: Chronic kidney disease (CKD) is now epidemic among HIV-infected populations in both Western and Eastern countries, and a likely determinant of their prognosis. The 2012 KDIGO CKD classification elaborated on how to identify patients at high risk for adverse outcomes. Methods: Distribution of CKD in 1976 HIV-infected subjects (1852 men, 124 women, mean age: 44.5 ± 11.5 years) who regularly visited one of the 5 tertiary hospitals was studied, based on the 2012 KDIGO CKD classification.