However, there is a paucity of information concerning the overall quality of implantation procedures as they are performed in various academic and nonacademic centers throughout the United States. Galunisertib mw In an effort to obtain information regarding the overall
quality of permanent seed implantation procedures as performed in the United States, Quality Research in Radiation Oncology (QRRO) performed a random survey of centers practicing prostate brachytherapy and obtained the postimplantation CT scans as well as dosimetric evaluations performed based on these scans. In a unique process, through a web-based remote deidentification process, postimplantation scans were downloaded to a central site from where they were extracted and underwent an independent evaluation by an expert institution. This report will summarize the dosimetric evaluation performed on these patients and compare these measures of quality to the dosimetric parameters submitted by the practicing institution. Of 414 eligible prostate cancer cases from 45 surveyed institutions, 86 patients received low-dose-rate brachytherapy
and were eligible for this study. We collected CT images, dose distributions, and contours from 59 of the 86 patients from 15 of 21 institutions with eligible cases. Nineteen cases were not used owing to the inability to retrieve the images (i.e., images no longer available in the submitting institution’s computer planning system, images stored in jpeg format only, or changes in software making it impossible for the site to transfer Antidiabetic Compound Library order image data without updating software they no longer used); for eight cases, portions of data were missing that would have been needed to complete the dosimetric analysis. In addition, there were 10 test cases from two institutions that selleck chemical were initially used from a community institution (which was similar to the rest of the sampled
cohort) and were included to increase the number of cases evaluated for a final study cohort of 69 cases. Institutions in each of the four strata (academic, large nonacademic, medium nonacademic, and small nonacademic) participated. The QRRO survey used stratified two-stage cluster sampling, with radiation oncology facilities from a master list of those operating in the United States in 2007 being stratified, a random sample of facilities selected from each stratum, and a random sample of eligible cases selected from each participating facility. Facility strata were classified as academic (main teaching hospital of a medical school or National Cancer Institute-designated Comprehensive Cancer Center), large nonacademic (facility with at least three linear accelerators actively treating the patients), medium nonacademic (facility with two linear accelerators actively treating the patients), and small nonacademic (facility with one linear accelerator actively treating the patients).