Instead, this pathophysiological effect may be restricted to infe

Instead, this pathophysiological effect may be restricted to infections displaying a relevant liver involvement. Further work is still necessary to define the full impact of infections in FGF15/19 function and to determine the underlying molecular mechanisms. Conclusions Through the alteration of the hepatobiliary function, bacterial pathogens of the enterohepatic system dysregulate the homeostasis of the FGF15/19-FGFR4 endocrine axis. These revealing findings have important implications for the understanding of the pathophysiology of microbial diseases.

Disruption of the FGF15/19-FGFR4 pathway may be a contributing factor to the metabolic and nutritional disorders associated with infectious diseases. Acknowledgments We thank Catherine Desrosiers, Melisange selleck compound Roux and Elora Midavaine for technical help. This work was supported by grants to A.M. from the Fonds de Recherche du Québec-Santé (26710) and the Natural Sciences and Engineering Research Council of Canada (401949–2011), and to B.B.F. from the Canadian Institutes for Health

Research. L. C. M. A. was funded by a postdoctoral fellowship from the Canadian Institutes of Health Research. A. M. is a member of the FRQS-funded Centre de Recherche Clinique Étienne-Le Bel. References 1. Powanda MC, Beisel WR: Metabolic effects of infection on protein and energy status. J Nutr 2003,133(1):322S-327S.PubMed 2. McGuinness OP: Defective glucose homeostasis during infection. Annu Rev Nutr 2005, 25:9–35.PubMedCrossRef 3. Khosla SN: Typhoyd fever. Its cause, transmission and prevention. New Delhi: Atlantic www.selleckchem.com/products/chir-99021-ct99021-hcl.html Publishers; 2008. 4. Antunes LC, Arena ET, Menendez A, Han J, Ferreira RB, Buckner MM, Lolic P, Madilao LL, Bohlmann J, Borchers CH, et al.: Impact of salmonella infection on host hormone metabolism revealed by metabolomics. Infect Immun 2011,79(4):1759–1769.PubMedCrossRef 5. Parry CM: Epidemiological and clinical aspects of human typhoid fever. In Salmonella infections:

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