Int J Cancer

2002, 98:596–603.CrossRef 29. Liede A, Malik IA, Aziz Z, Rios P, Kwan E, Narod SA: Contribution of BRCAl and BRCA2 mutations to breast and ovarian cancer in Pakistan. Am J Hum Genet 2002, 71:595–606.PubMedCrossRef 30. Lied A, Narod SA: Hereditary breast and ovarian cancer in Asia: Genetic epidemiology of BRCA1 and BRCA2. Human Mutation 2002, 20:413–424.CrossRef 31. Goelen G, Teugels E, Bonduelle M, Neyns B, DeGreive J: High frequency GDC-0449 manufacturer of BRCA1/2 germline mutations in 42 Belgian families with a small number of symptomatic subjects. J Med Genet 1999, 36:304–308.PubMed 32. Corski B, Byrski T, Huzarski T, Jakubowska A: Founder mutations in the BRCA1 gene in polish families with breast-ovarian cancer. Am J Hum Genet 2000, 66:1963–1968.CrossRef 33. Bar-Sade RB, Kruglikova A, MoDan B, Gak E: The 185 del AG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim. Hum Mol Genet 1998, 7:801–805.PubMedCrossRef 34. Osorio A, Robledo M, Albertos J, Diez O: Molecular analysis of the six most recurrent mutations in the BRCA1 gene in 87 Spanish breast/ovarian cancer families. Cancer 1998, 123:153–158. 35. Stoppa D, Laurent P, Essioux L, Pages S: BRCA1 sequence variations in 160 individuals referred to a breast/ovarian family

cancer clinic. Am J Hum Genet 1997, 60:1021–1030. 36. Kumar BV, Lakhotia S, Ankathil R, Madhavan VX-689 nmr J: Germline BRCA1 mutation analysis in Indian Breast/ovarian cancer families. Cancer biology and therapy 2002, 1:18–21.PubMed 37. Hamann U, Liu X, Bungardt N, Ulmar H, Bastert G, Sinn HP: Similar Contributions of BRCAl and BRCA2 germline mutations to early-onset breast cancer in Germany. European J nearly Hum Genet 2003, 11:464–467.CrossRef 38. Frank TS,

Deffenbaugh AM, Reid JE, Hulick M: Clinical characteristics of individuals with germline mutations in BRCAl and BRCA2: Analysis of 10.000 individuals. J Clin Oncol 2002, 20:1480–1490.PubMedCrossRef 39. Gayther SA, Mangion J, Russell P, Seal S, Barfoot R: Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nat Genet 1997, 15:103–105.PubMedCrossRef 40. Ramus SJ, Fishamn A, Pharoah PD, Yarkoni S, Altaras M, Ponder BA: Ovarian Cancer survival in Ashkenazi Jewish patients with BRCAl and BRCA2 mutations. Eur J Surg Oncol 2001, 27:278–281.PubMedCrossRef 41. Neuhausen S, Mazoyer S, Friedman L, Stratton M: Haplotype and Phenotype analaysis of six recurrent BRCA1 mutations in 61 families. Am J Hum Genel 1996, 58:271–280. 42. Vander luijt RB, Avanzon PHA, Jansen RPM: De novo recurrent germline mutation of the BRCA2 gene in a patient with early onset breast cancer. J Med Genet 2001, 38:102–105.CrossRef 43. Ramus SJ, Friedman LS, Gayther SA, Ponder BAJ: A breast/ovarian patient with germline mutations in both BRCAl and BRCA2. Nat Genet 1997, 15:14–15.PubMedCrossRef 44.