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endolysins-current state of research and applications. Curr Opin Microbiol 2005,8(4):480–7.PubMedCrossRef 43. Kluytmans J, van Belkum A, Verbrugh H: Nasal carriage of VRT752271 price Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 1997,10(3):505–20.PubMed 44. von Eiff C, Becker K, Machka K, Stammer H, Peters G: Nasal Carriage MK5108 supplier as a Source of Staphylococcus Aureus Bacteremia Study Group. N Engl J Med 2001, 344:11–6.PubMedCrossRef 45. Lamers RP, Stinnett JW, Muthukrishnan G, Parkinson CL, Cole AM: Evolutionary analyses of Staphylococcus aureus identify genetic relationships between nasal carriage and clinical isolates. PLoS One 2011,21; 6(1):e16426.CrossRef 46. van Rijen M, Bonten M, Wenzel R, Kluytmans J: Mupirocin ointment for

preventing Staphylococcus aureus infections in nasal carriers. Cochrane Database Syst Rev 2008,8(4):CD006216. 47. Hogue JS, Buttke P, Braun LE, Fairchok MP: Mupirocin Resistance Related to Increasing Mupirocin Use in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in a Pediatric Population. J Clin Microbiol 2010,48(7):2599–2600.PubMedCrossRef 48. Han Ribonucleotide reductase LL, McDougal LK, Gorwitz RJ, Mayer KH, Patel JB, Sennott JM, Fontana JL: High Frequencies of Clindamycin and Tetracycline Resistance in Methicillin-Resistant Staphylococcus aureus Pulsed-Field Type USA300 Isolates Collected at a Boston Ambulatory Health Center. J Clin Microbiol 2007, 45:1350–2.PubMedCrossRef Competing interests Authors SP, VDP, SSR, and BS are inventors on the filed patent (Phage-derived antimicrobial agents: International publication Number WO2007/130655) describing methods and therapeutic compositions to reduce infections and methods for identifying additional such compositions. Authors have assigned rights to Gangagen Inc. which, is a current employer of BS, SS, SSR, SEG, RC, MD and a previous employer of SP, VDP, JYA, and RP. Authors’ contributions SP and BS participated in study design and coordination and contributed to data interpretation.

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