001, rank-sum test). In the following, we will present gamma-band activity by analyzing signals at 45 Hz because this activity displayed the strongest spatially selective persistent memory activity across the population of recordings (see below). At 45 Hz, we found that LFP power was not significantly selective for either RT (SRT: p = 0.32, RRT: p = 0.67, rank-sum

test). We obtained similar results at other frequencies above 30 Hz (For example, at 65 Hz, SRT: p = 0.11, RRT: p = 0.23, rank-sum test). Since greater beta-band LFP power is associated with slower RTs, decreasing beta-band LFP power AT13387 clinical trial may speed movement initiation. The RT selectivity of beta-band LFP power before a reach and saccade is spatially specific and present before movements to the preferred direction. Before movements to the null direction, the activity was not significantly greater during slow trials regardless of whether activity was sorted by saccade RT or reach RT (Figures 4C and 4D; RRT: p = 0.43. SRT: p = this website 0.27, rank-sum test). To further establish the specificity of beta-band activity for specific interactions between reach and saccade processes, we asked whether RT

selectivity is also present when saccades are made alone. There was no significant difference between activity across the population for the fast versus slow RTs when saccades were made alone in the preferred direction (Figure 4E; at 15 Hz, p = 0.18, rank-sum test) or the null direction (Figure 4F; at 15 Hz, p = 0.63, rank-sum test). Lack of RT selectivity Hydroxychloroquine nmr before saccades is also not associated with a lack of spatial selectivity. LFP activity was significantly greater for saccades in the preferred direction than in the null direction (Figures 4E and 4F; Supplemental Information). Therefore, beta-band LFP power in area LIP correlates with SRT only when a saccade is made with a coordinated reach in the preferred direction. The level of beta-band power before movements to the preferred direction, however, is greater before saccades made alone than before coordinated movements. Since SRTs are faster before coordinated reach and

saccade movements than before saccades made alone, this is consistent with increasing beta-band activity slowing down movement initiation. The overall picture is that beta-band activity exerts a braking mechanism to control the timing of saccades with reaches. Next, we determined whether beta-band selectivity for RT was also present in the spiking activity of area LIP neurons. We recorded isolated action potentials from 59 neurons that showed spatially tuned activity before a coordinated reach and saccade (p < 0.05; permutation test, 48 neurons in Monkey H; 11 neurons in Monkey J). To determine whether spiking activity that is coherent with beta-band LFP activity also predicts RT, we first divided neurons into two groups: coherent cells and not coherent cells.