27; 95% CI 0.06–1.15, P = 0.066, chi-squared test). However, there was no significant relation between the degree of eGFR improvement and delay in starting steroids (Pearson selleck r = −0.25, P > 0.45), and no difference in eGFR at the time of last follow-up (StG: 33 ± 3; SnG: 32 ± 7; P > 0.9, unpaired t-test). Conclusion: StG patients had a greater degree of improvement in renal function, but with no correlation between degree
of improvement in eGFR and delay in starting steroids, and similar eGFR values at final follow-up. PPI were the second commonest drug category among drug-induced cases. “
“The current study was designed to observe the ultrastructural changes of podocyte foot processes during the remission phase and its relationship with the amount of the proteinuria in patients with minimal change disease (MCD). Electron micrographs of glomerular capillaries were taken from 33 adult cases with MCD, including 12 cases with nephrotic syndrome, 15 cases in partial remission and six cases in complete remission. The foot processes were classified into three grades by the ratio of the height to basal width: 0.5–1, 1–2 and ≥2. The foot process width (FPW) and the number
of foot processes in different grades per 10 μm of glomerular basement membrane (GBM) were measured. Normal renal tissues from 12 nephrectomies for DAPT solubility dmso renal carcinoma were selected as controls. There were statistical differences (P = 0.001) in the mean FPW among the nephrotic group (1566.4 ± 429.4 nm), partial remission group
(1007.8 ± 234.9 nm), complete remission group (949.8 ± 168.2 nm) and normal controls (471.9 ± 51.8 nm). For the height-to-width ratio ≥2, the number of foot process per 10 μm GBM was significantly greater in the normal group than that in the complete remission group (0.84 ± 0.24 vs. 3.84 ± 1.80, P = 0.016). Taking all three groups of patients together, the mean FPW showed correlation with the level of proteinuria (r = 0.506, P = 0.003). There may be no causal relationship between proteinuria and foot process effacement. In complete remission phase, both FPW and shape of foot process had not returned to normal while proteinuria disappeared. “
“The Chronic Kidney Disease Collaboration – Epidemiology (CKD-EPI) glomerular filtration rates (GFR) estimation many equation is believed to estimate GFR more accurately in healthy people but this has not been validated in Asians. We studied the distribution of GFR in a multi-ethnic Asian population without CKD, and compared the performance of measures of GFR estimation, including the CKD-EPI equation, Cockroft-Gault equation, and 24-hour urine creatinine clearances. A total of 103 healthy volunteers without a history of kidney disease, hypertension, or diabetes underwent GFR measurement using 3-sample plasma clearance of 99mTc-DTPA. Cockroft-Gault estimated GFR and 24-hour urine creatinine clearances were normalized to body surface area.