3 ± 1 2 g/kg body mass; 53 ± 14%, respectively) of protein

3 ± 1.2 g/kg body mass; 53 ± 14%, respectively) of Lazertinib supplier protein during the first half of the event and 82 ± 52 g (1.1 ± 0.7 g/kg

body mass; 47 ± 14%, respectively) during the second. During the first 12-hour period, the cyclists ingested 59 ± 35 g (0.8 ± 0.5 g/kg of body mass; 55 ± 13%, respectively) of lipid and 48 ± 31 g (0.7 ± 0.4 g/kg of body mass; 45 ± 13%, respectively) during the second period. Table 3 Macronutrient intake during the event. Subjects 1 2 3 4 5 6 7 8 Mean ± SD Carbohydrates Foretinib mw                      Solids (g) 284 392 290 252 695 323 668 378 533 ± 175    Fluids (g) 538 533 442 566 889 574 456 268 410 ± 174    Total (g) 822 925 732 818 1584 897 1124 647 943 ± 295 g/kg a 12.4 13.5 9.4 12.3 21.4 11.9 15.2 8.8 13.1 ± 4.0 g/min b 2.06 2.55 1.91 2.70 3.12 2.66 3.77 2.11 2.61 ± 0.62 % c 77.3 80.2 76.6 81.4 62.6 64.8 67.0 59.3 71.1 ± 8.7 Protein                      Solids (g) 62 66 41 37 262 146 126 128 109 ± 75    Fluids (g) 35 25 35 33

245 80 60 8 65 ± 76    Total (g) 97 91 76 69 507 226 186 136 174 ± 146 g/kg 1.5 1.3 1.0 1.0 6.9 3.0 2.5 1.9 2.4 ± 1.9 % 9.2 8.0 8.1 6.9 20.2 16.1 11.2 12.7 11.5 ± 4.6 Ratio CHO: P (g) d 8.5 10.2 9.6 11.9 3.1 4.0 6.0 4.7 7.2 ± 3.2 Lipids                      Solids (g) 47 52 48 37 159 91 142 131 88 ± 49    Fluids (g) 17 10 17 15 42 25 22 5 19 ± 11    Total (g) 64 62 64 52 201

116 164 136 107 ± 56 g/kg 1.0 0.9 0.8 0.8 2.7 1.6 2.3 1.9 1.5 ± 0.7 % 13.7 12.2 15.3 11.8 18.0 18.6 22.2 28.3 17.4 ± 5.6 a Ratio between total macronutrient intake (g) and body mass (kg) at the Salubrinal research buy beginning of the event. b Ratio between total carbohydrate intake (g) and total racing time (min) c Percentage of the second total energy intake d Ratio CHO: P (g): Ratio of total grams of carbohydrate intake in relation to total grams of protein during the event. Fluid, sodium and caffeine intake Total fluid balance and sodium intake are illustrated in Table 4. Overall fluid consumption during the first half of the race (1900 – 0700 h) was 4794 ± 1633 mL (46 ± 7%) and 5703 ± 1421 mL (54 ± 7%) during the second (0700 – 1900 h), respectively. In relation to racing and recovery time, the cyclists ingested 907 ± 90 and 285 ± 128 mL/h, respectively. Overall fluid consumption showed that water (150 ± 48 mL/h) and sports drinks (139 ± 91 mL/h) were the main fluids ingested (Figure 2). The average sodium intake was 1189 ± 929 mg (5.2 ± 2.6 mmol/L of total fluid intake) and 3144 ± 2128 mg (17.8 ± 10.2 mmol/L) in fluids and solids, respectively.

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