3, which was also found, associated with tumorigenicity . In this study, we showed that Mir-29a negatively regulated expression of B-Myb (Figure 5), which is a transcription factor broadly involved in regulating cell cycle and apoptosis and probably is a promoting factor for cancer . Downstream effectors of B-Myb,
such as Cyclin A2 and D1, were also correspondingly regulated by Mir-29a. Cyclin D1 is one of highly over-expressed proteins in breast cancer cells and over-expression of Cyclin D1 protein was found in 40-90% of cases of invasive breast cancer . Cyclin CHIR98014 purchase A2 is involved in S phase and G2-M phase transition and is also over-expressed in various cancers [29–31]. Taken together, in current paper, we showed that Mir-29a may act as a tumor suppressor through its inhibitory function on growth of breast cancer cells, and down-regulating expression of B-Myb by Mir-29a may contribute AZD2281 purchase to this process. References 1. Jemal A, et al.: Cancer statistics, 2009. CA Cancer J Clin 2009,59(4):225–249.PubMedCrossRef 2. Lin Y, et al.: Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study. J Exp Clin Cancer Res 2013,32(1):53.PubMedCentralPubMedCrossRef 3. Iorio MV, et al.: MicroRNA gene expression deregulation in human
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