3, which was also found, associated with tumorigenicity [26] In

3, which was also found, associated with tumorigenicity [26]. In this study, we showed that Mir-29a negatively regulated expression of B-Myb (Figure 5), which is a transcription factor broadly involved in regulating cell cycle and apoptosis and probably is a promoting factor for cancer [27]. Downstream effectors of B-Myb,

such as Cyclin A2 and D1, were also correspondingly regulated by Mir-29a. Cyclin D1 is one of highly over-expressed proteins in breast cancer cells and over-expression of Cyclin D1 protein was found in 40-90% of cases of invasive breast cancer [28]. Cyclin CHIR98014 purchase A2 is involved in S phase and G2-M phase transition and is also over-expressed in various cancers [29–31]. Taken together, in current paper, we showed that Mir-29a may act as a tumor suppressor through its inhibitory function on growth of breast cancer cells, and down-regulating expression of B-Myb by Mir-29a may contribute AZD2281 purchase to this process. References 1. Jemal A, et al.: Cancer statistics, 2009. CA Cancer J Clin 2009,59(4):225–249.PubMedCrossRef 2. Lin Y, et al.: Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study. J Exp Clin Cancer Res 2013,32(1):53.PubMedCentralPubMedCrossRef 3. Iorio MV, et al.: MicroRNA gene expression deregulation in human

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Clin Cancer Res 2012, 31:58.PubMedCentralPubMedCrossRef 5. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 2009,136(2):215–233.PubMedCentralPubMedCrossRef 6. Chen F, Hu SJ: Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review. J Biochem Mol Toxicol 2012,26(2):79–86.PubMedCrossRef 7. He L, Hannon GJ: MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004,5(7):522–531.PubMedCrossRef 8. Plaisier CL, Pan M, Baliga NS: A miRNA-regulatory network explains how dysregulated miRNAs perturb oncogenic processes Rucaparib across diverse cancers. Genome Res 2012,22(11):2302–2314.PubMedCentralPubMedCrossRef 9. Fan MQ, et al.: Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma. J Exp Clin Cancer Res 2013,32(1):21.PubMedCentralPubMedCrossRef 10. Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 2006,6(11):857–866.PubMedCrossRef 11. Creighton CJ, et al.: Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One 2012,7(3):e34546.PubMedCentralPubMedCrossRef 12. Zhao JJ, et al.: MicroRNA expression profile and identification of miR-29 as a AZD3965 prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood 2010,115(13):2630–2639.PubMedCentralPubMedCrossRef 13. Garzon R, et al.

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