37 Furthermore, after prolonged and effective control of HBV replication in patients treated with potent antivirals, an add-on application of anti-HBs may facilitate HBsAg clearance in appropriately selected patients. The authors thank Eithan Galun, principal investigator of the clinical investigation,13 which provided data for mathematical modeling, and Dov Terkieltaub for technical assistance. Additional Supporting Information may be found in the online version of this article. “
“Gastric adenocarcinoma GS 1101 is the second leading cause of cancer death worldwide. It is more prevalent in males in Asia. Helicobacter pylori
infection plays a major role in the pathogenesis of gastric cancer. Endoscopy is the most valuable and commonly used
technique for diagnosis of gastric cancer. Surgery remains the curable therapy for resectable disease. Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) can be useful for treatment of early gastric cancer. “
“Non-alcoholic steatohepatitis (NASH) is the hepatic PLX-4720 solubility dmso manifestation of metabolic syndrome (MS). Monosodium glutamate (MSG)-treated ICR mice is a useful model of MS and NASH, but it shows the different patterns of steatosis from human NASH. Because inbred aged DIAR (ddY, Institute for Animal Reproduction) mice spontaneously show the similar pattern of steatosis as NASH, we analyzed their liver pathology after administering MSG. MSG-treated DIAR mice (DIAR-MSG) and untreated DIAR mice (DIAR-controls)
were sacrificed and assessed histopathologically at 29, 32, 40, 48, and 54 weeks of age. The NASH 上海皓元医药股份有限公司 activity score, body mass index, blood glucose level, and oral glucose tolerance test were also assessed. The body mass index and blood glucose levels of DIAR-MSG were significantly higher than controls. The oral glucose tolerance test revealed a type 2 diabetes pattern in DIAR-MSG. The livers of DIAR-MSG mice showed macrovesicular steatosis, lobular inflammation with neutrophils, and ballooning degeneration after 29 weeks. At 54 weeks, mild fibrosis was observed in 5/6 DIAR-MSG and 2/5 DIAR-control mice. In imaging mass spectrometry analysis, cholesterol as well as triglyceride accumulated in the liver of DIAR-MSG mice. Atypical liver nodules were also observed after 32 weeks in DIAR-MSG, some with cellular and structural atypia mimicking human hepatocellular carcinoma. The NASH activity score of DIAR-MSG after 29 weeks was higher than that of control mice, suggesting the development of NASH. DIAR-MSG had NASH-like liver pathology and liver nodules typically associated with MS symptoms. DIAR-MSG provides a valuable animal model to analyze NASH pathogenesis and carcinogenesis.