Serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitors (SNRIs), are widely used to treat panic disorder and depression, and ameliorated OAB in selected patients. These drugs are thought to act on both efferent and afferent fibers from the bladder. On the other hand, brain corticotropin-releasing factor (CRF) has anxiogenic effects and increases
bladder sensation. Irritable bowel syndrome is highly prevalent in anxiety and mood disorders, and CRF receptor antagonists could ameliorate increased bowel sensation in those patients. selleck chemicals These findings suggest that increased bladder sensation can be a reflection of biological changes in both the emotion and micturition circuits within the brain. In contrast, the emotional mechanism
underlying the underactive/acontractile detrusor is not well understood. Neurogenic cases such as brain tumor and stroke[57, 58] and functional imaging studies[15, 16] have suggested that the cingulate cortex and insular cortex are the key areas for the generation of micturition impulses, which are sent to the brainstem structures. Therefore, functional changes in these areas might also occur in depressive/anxious patients with bladder Y-27632 nmr dysfunction. In somatoform disorders other than autonomic, functional neuroimaging studies have shown a decrease in the activity of frontal and subcortical circuits involved in motor control, and increases in the activities of supplementary motor area and midline regions for hysterical
motor paralysis.[59-61] However, in somatoform disorder of the bladder, no functional neuroimaging Ceramide glucosyltransferase studies are available. Serotonergic and GABAergic drugs are the mainstay in the treatment of depression/anxiety. What is the effect of these drugs on the bladder function? Central serotonergic neurons participate in a variety of physiological functions. Recent evidence has shown that centrally administered serotonin has modulatory effects on bladder function, the main actions of which are facilitation of urine storage.[52, 62] While inhibiting the bladder, serotonin facilitates sacral anterior horn cells innervating the urethra, presumably via inhibitory interneurons, leading to urethral contraction.[52, 63] Most central serotonin is physiologically released from nerve terminals of the brainstem raphe nucleus. There is a variety of micturition-related neuronal activity in the raphe nucleus, and microstimulation has been shown to elicit inhibition of the bladder. This effect might be due to activation of the raphe-spinal descending pathways, which in turn suppresses the sacral preganglionic neurons via inhibitory serotonin 1A receptors; it might also be due to suppression of the sensory afferent in the spinal posterior horn.