A family history of Charcot-Marie-Tooth disease was revealed late in his presentation, and genetic testing identified a mutation in the GJB1 gene that has not previously been associated with central nervous system involvement.”
“The objective of this study was to evaluate the measurement equivalence of an interactive
voice response system (IVRS) version and the original paper-based version of the EORTC QLQ-C30.
The QLQ-C30 is a cancer-specific, health-related quality of life questionnaire consisting of nine multi-item scales (physical, role, emotional, cognitive and social functioning, fatigue, nausea/vomiting, pain, and quality of life) and six single item measures (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial problems). This NCT-501 inhibitor study utilized a crossover design with subjects randomly assigned to one of two assessment orders: (1) paper then IVRS or (2) IVRS then paper. Equivalence between the two administration modes was established by comparing the 95 % lower confidence
interval (CI) of the intraclass correlation coefficients (ICCs) for each scale, with a critical value of 0.70.
The ICCs for the nine multi-item scales were all above 0.79, ranging from 0.791 to 0.899 (ICC 95 % lower CI range 0.726-0.865) and significantly different from our threshold reliability of 0.70. The ICCs for the six single items DZNeP datasheet ranged from 0.689 to 0.896 (ICC 95 % lower CI range 0.611-0.888). Two of the items, insomnia JQ-EZ-05 supplier and appetite loss, were not statistically different from 0.70. When considered together, the per-protocol analysis results support the equivalence of the paper and IVRS versions of the QLQ-C30 for 13 of the 15 scores.
This analysis provides evidence that the scores obtained from the IVRS version of the QLQ-C30 are equivalent to those obtained with the original paper version except for the insomnia and appetite loss items.”
“Using a sample of 347 prison inmates and general linear modeling (GLM) repeated measures analyses, this paper examined during-treatment responses (e.g., changes in psychological and social
functioning) to prison-based TC drug treatment. These effects have rarely been examined in previous studies, and never with a fully multivariate model accounting for within-subjects effects (changes over time), between-subjects effects (e.g., levels of risk and motivation), and within/between-subjects interactions (time x risk x motivation). The results provide evidence of positive inmate change in response to prison TC treatment, but the patterns of results varied depending upon: (a) specific indicators of psychological and social functioning, motivation, and treatment process; (b) the time periods examined (I, 6, and 12 months during treatment); and (c) baseline levels of risk and motivation. Significant interactions between time and type of inmate suggest important new directions for research, theory, and practice in offender-based substance abuse treatment. (C) 2009 Elsevier Ireland Ltd.