“
“A new tetrahydrobenzofuran derivative, (6S, 7S)-6,7-dihydroxy-3,6-dimethyl-2-isovaleroyl-4,5,6,7-tetrahydrobenzofuran find more (1),

together with the known 1,2-dihydroxymintlactone (2), was isolated from the fermentation broth of the edible mushroom fungus Lentinus squarrosulus BCC 22366. The structure was elucidated by interpretation of NMR spectroscopic and mass spectrometry data. The absolute configuration of 1 was addressed by application of the modified Mosher’s method. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Objective: To develop a culturally adapted Bengali version of the Short Form-36 (SF-36) Health Survey and to test its acceptability, reliability, and validity in patients with rheumatoid arthritis (RA).

Study Design and Setting: The US English SF-36 was translated into Bengali after established cross-cultural adaptation procedures. The questionnaire was interviewer administered to 125 consecutive outpatients with RA and readministered after 2 weeks to 40 randomly selected patients.

Results:

ICG-001 supplier Most participants (86.4%) did not have any problem in understanding the Bengali SF-36 and 98.4% of the questionnaires were fully completed. Only the role-physical and role-emotional scales showed substantial floor and ceiling effects. Principal component analysis confirmed that the hypothesized two-factor structure and tests of scaling assumptions were 100% successful for all eight scales expect physical functioning (98.8%) and general health (77.5%). Cronbach’s alpha was higher than 0.78 and the test-retest reliability was high (r > 0.82) for all scales. Correlations with other disease activity parameters were generally as expected and summary scores were able to discriminate between relevant subgroups.

Conclusion: The interviewer-administered Bengali SF-36 appears to be an acceptable,

reliable, and valid instrument for measuring health-related quality see more of life in Bangladeshi patients with RA. The questionnaire should be further evaluated in people from the general population and in patients with different medical conditions. (C) 2012 Elsevier Inc. All rights reserved.”
“Evidence for the assumption that cannabis use is associated with depression and depressive symptoms is inconsistent and mostly weak. It is likely that the mixed results are due to the fact that prior studies ignored the moderating effects of an individual’s genetic vulnerability. The present study takes a first step in scrutinizing the relationship between cannabis use and depressive symptoms by taking a developmental molecular-genetic perspective.