ed dose of flavopiridol ALK inhibitor in clinical trials treatment. Due to concerns for tumor lysis syndrome with split-dose schedule blood samples were obtained from tumor lysis, including LDH, calcium, magnesium and phosphorus, the day after treatment. If necessary, dexrazoxane was given before each dose of doxorubicin. Dexrazoxane was given 10 times the dose of doxorubicin. Doxorubicin was within 30 minutes after start of infusion given dexrazoxane. After 600 mg/m2 of doxorubicin, doxorubicin was discontinued and flavopiridol was prosecuted as a single agent until disease progression. All treatments were administered and intra-patient dose escalation patient was not allowed. The toxicity of t has been classified in accordance with the Common Toxicity Criteria version 3.0. Doselimiting toxicity t is defined as the occurrence in the first round of grade 4 h Dermatological toxicity t 21 days after treatment, grade 4 toxicity Tended period of 7 days or more, grade 3 or 4 non-h dermatological toxicity defined t including normal diarrhea despite prophylaxis against diarrhea, nausea despite antiemetic treatment mpfen to Ampicillin, and any delay Storage at the processing of more than two weeks. The maximum tolerated dose was defined as the dose one level below the dose at which two or more patients experienced DLT in the first dose w Defined during the first treatment. Patients, DLT or toxicity Study medication due t learned nnten k Continue to benefit from a treatment study after recovery, defined by corresponding adjustment of the dose by the Protocol.
To be evaluable for response and evaluated for the determination of BAT, patients had to be re-used U at least one full cycle of therapy. Otherwise, reactions were evaluated for the treatment after every two cycles with CT or other diagnostic tests, if at all. Response criteria in solid tumors, version 1.0, were used to assess response and conducted by an independent radiologist Ngig by the protocol. Complete Ndiger or partial responses were were met by repeated examinations at least 4 weeks after the reaction criteria best CONFIRMS. The main objective epigallocatechin of this study, the MTD or maximum target dose was identified by flavopiridol, when administered in combination with doxorubicin to be determined. Standard 3 3 was used for the construction of dose escalation. The incidence of h Dermatological and h Dermatological toxicity Th were summarized separately by cohort flavopiridol. Secondary ranalysen A pharmacokinetic analysis of flavopiridol by non-compartmental methods included. In vitro combinations of doxorubicin and flavopiridol were statistically superior to doxorubicin alone or flavopiridol.
As shown in Figure 1A, the tests showed that colony formation compared to doxorubicin alone or flavopiridol, observable colonies fa reduced Is substantially tested with all the combinations. For example, colony formation decreased by 59%, with only 41% with flavopiridol to the accompanying therapy, 35% with doxorubicin followed by flavopiridol and 44% with flavopiridol followed by doxorubicin. Although it was observed a tendency F doxorubicin Promotion colony formation by flavopiridol was no statistically significant difference in colony formation for the three combinations, followed by decrease. However, when these combinations for the induction of apoptosis were examined b.