Re insignificant 55.0. It seems that if the Bay 43-9006 Nexavar fusion of PEG / PEO has a balancing effect on the release rate of extrusion. What PEG / PEO is used, the release rate that results is identical to that, the PEG / PEO background may need during the extrusion. The release profile of the PEO 7 million other hand, differs markedly from the trailer Ufung curve 43.1. Apart from the difference of the molecular weights, it appears that melting of the PEG / PEO has a significant influence on the rate of release have. These results suggest that to determine the fusion of PEG is an important process, the release behavior of extruded part. 3.8. Various PEG / PEO release and Change of effects in a matrix trimyristin To select these findings, the same tests by replacing tristearin trimyristin were carried out, k Can solid fat and that1996 substantially eliminating the problems with the Sch the wetted rfe Carbopol connected. Interestingly, the roundness and softness were beads, Carbopol 974P h Depends on the nature of the electrolyte. Image analysis shows that beads, calcium chloride in the formulation sph Step beads, potassium, sodium, magnesium or aluminum Imatinib CGP-57148B chloride. Micrograph images showed that beads, calcium chloride was also smooth surface Surface. Therefore, calcium chloride was selected for solid electrolyte for use in subsequent studies by weight. To remove the minimum concentration of calcium chloride is essential for the development of wet sticky because Carbopol shown to be dependent ngig, the content of Carbopol 974P, as described in the following equation: 0.635% CaCl2 concentration × 100.0329C where C the percentage of dry matter in the carbopol. This minimum erm Glichte the production of smooth, essentially spherical Shaped pearls. The water demand, to produce the wet mass was, of R, the ratio Ratio were of Carbopol 974P to mass percent in the formulation Avicel PH101 310 ml OF WATER 97.4R These two equations, each of which were on a batch of 300 g based on this study used to determine the levels of these components for use to calculate in moist mass. Caffeine, chlorpheniramine maleate and diphenhydramine hydrochloride dyphylline were selected for this study hlt To the influence of water- And solubility of the salt form of the drug release rate to investigate. In the case of non-electrolytes, was dyphylline as xanthine derivative L Soluble in water, 333 COOLED mg / ml and caffeine l as a less Sliches a selected, 20 mg / ml chlorpheniramine maleate an L Solubility, 160 mg / ml, what about, half of the dyphylline, w while diphenhydramine hydrochloride as an L sliches highlywater salt, 1000 mg / ml of selected just increments, with an L solubility greater than that of dyphylline. In this way There are L Considered shown Aurora Kinase A,B,C solubility of high and low both in the non-electrolytes and salts, and a plurality of L Solubilities. Are protected by the use of pairs of drugs that Similar molecular size And shape, the diffusion of the pair of molecules through the release agent would be expected that Be similar. Since the Fick’s diffusion typically is a foreigners Semechanismus of Ger Th based on hydrophilic polymers, differences in the rate of release or foreigners Should semechanismus drugs between the pair.