Mmenced of the drug in the eye and in the cohort were included for analysis. These three subjects Bcr-Abl inhibitor in clinical trials had increased after the treatment, Ma To other treatments. The authors found that both trailing and not lowering IOP clearly associated with therapeutic response, as measured by the difference between the average pretreatment IOPs 3 and 3 after treatment. This study differs from the n Be in many ways. The ITT visit the OHTS were not included in the analysis, and it is likely that all subsequent measurements PIO been measured from the mean regression, reducing the size E the effect of the monocular trial. Second, the use of three measurements, the pre-treatment over a period of 18 months at best term Whether a therapeutic intervention is necessary not occur repr Representative for the clinical practice.
Close Lich have patients who have a therapeutic effect was not achieved eliminated, the introduction of an important bias source and reduce the performance of the action of the monocular test. Our study results much use of the monocular trial of treatment in favor of mk-2866 Androgen Receptor inhibitor this group of patients for treatment naive ï treated with prostaglandin analogues. The mean error of the observed effect of treatment was removed and was in a case Caseby the size E of the error is significantly reduced from 3.8 to 2.1 mm Hg. Equally important, the error variance was significantly reduced due to the effects of monocular study on the number of very inaccurate Sch Estimates of the impact. Using the unadjusted results, was the treatment effect of the tats Chlichen effect of 6 mmHg in 8 cases F, But this was reduced to a single case, using the adjusted results.
One reason for the effectiveness of the treatment study monocular which the problem of regression to mean.22 The IOP fluctuates to a certain Ausma Bosutinib in all patients. In a real situation, we have tried to emulate in this study, it is more likely than not a patient, the treatment is started, if their IOP h Ago is considered to be their mean IOP. Inevitably, then, that more often than not, when the patient returns to the clinic for treatment, a part of the observed efficacy of the drug is tats Chlich on the natural recovery are ascribed by their return on the average IOP. In this study this effect in the reduction of intraocular pressure between recruitment and baseline measurements contradicts.
However, the point Ant IOP recruiting for an additionally USEFUL reference IOP does not eliminate the advantage of testing behind his monocular R In contr The day Dayto fluctuations in intraocular pressure, and the regression to the mean. The alternative approach for the accurate measurement of the effect of drugs for glaucoma, the IOP measurements in the other and / or after initiation of treatment to make. Our data suggest that the use of a reference measurement and an erg Complementary Ma Exception additionally USEFUL treatment almost as accurate as using a monocular trial of treatment requires two visits. The effectiveness of the treatment requires a high degree monocular Ma of symmetry in the background fluctuation in IOP between the two eyes. In this study, the reduction of intraocular pressure between the base and recruiting highly correlated between the two eyes. The study revealed a much h Press here Precision monocular