Objective To investigate the worth of reconstruction of pelvic flooring with biological items to avoid and treat empty pelvic problem after pelvic exenteration (PE) for locally advanced or recurrent rectal disease. Practices This was a descriptive study of data of 56 clients with locally advanced level or locally recurrent rectal cancer without or with restricted extra-pelvic metastases who had encountered PE and pelvic flooring reconstruction using cellar membrane layer biologic services and products to split up the abdominal and pelvic cavities when you look at the division of Anorectal Surgical treatment of this 2nd Affiliated Hospital of Naval Military health University from November 2021 to May 2022. The degree of surgery was divided in to two categories mainly inside the pelvis (41 patients) and including pelvic wall resection (15 customers). In most treatments, basement membrane CNS nanomedicine biologic products were utilized to reconstruct the pelvic flooring and separate the abdominal and pelvic cavities. The procedures included a transperitoneal approach, for which biologic ities during PE for locally advanced or recurrent rectal cancer is safe, efficient, and feasible. It improves the perioperative security of PE and warrants much more implementation.Objective To research the medical indications and perioperative medical outcomes of pelvic exenteration (PE) for locally advanced level, recurrent pelvic malignancies and complex pelvic fistulas. Methods it was a descriptive study.The indications for carrying out PE had been (1) locally advanced, recurrent pelvic malignancy or complex pelvic fistula identified preoperatively by imaging and pathological study of a biopsy; (2)preoperative contract by a multi-disciplinary staff that non-surgical and standard surgical procedure had failed and PE was needed; and (3) conclusions on intraoperative exploration guaranteeing this conclusion.Contraindications to this medical procedure comprised cardiac and respiratory dysfunction, poor health status,and mental state too poor to tolerate the procedure.Clinical data of 141 patients which met the aforementioned criteria, had encountered PE in the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to September 2022, had complete perioperative medical data, andmpleted. Complete PE was carried out on 73 patients (51.8%),anterior PE on 22 (15.6%),and posterior PE in 46 (32.6%). The median operative time was 576 (453,679) mins, median intraoperative blood loss 500 (200, 1 200) ml, and median hospital stay 17 (13.0,30.5)days.There were no intraoperative deaths. Of this 89 clients assessed for radical PE surgery, the radical R0 resection ended up being attained in 64 (71.9%) of those, R1 resection in 23 (25.8%), and R2 resection in 2 (2.2%). One or more postoperative complications took place 85 cases (60.3%), 32 (22.7%)of which were Clavien-Dindo grade III and above.One client (0.7%)died during the perioperative period. Conclusion PE is a legitimate selection for treating locally advanced level or recurrent pelvic malignancies and complex pelvic fistulas.Objective To explore the feasibility, protection, and short- and long-term efficacy of laparoscopic pelvic exenteration (LPE) in treating locally advanced rectal cancer. Techniques The clinical information of 173 clients that has withstood pelvic exenteration (PE) for locally advanced rectal cancer tumors that had been shown by preoperative imaging or intraoperative research to possess invaded beyond the mesorectal excision airplane and adjacent organs within the Cancer Hospital, Chinese Academy of Medical Sciences (n=64) and Peking University First Hospital (n=109) from 2010 January to 2021 December were collected retrospectively. Laparoscopic PE (LPE) was performed on 82 of the customers and open PE (OPE) on 91. Short- and long-lasting effects (1-, 3-, and 5-year total and disease-free success and 1- and 3-year cumulative regional recurrence rates) had been compared between these teams. Results the only real statistically considerable difference in standard information between the two groups (P>0.05) had been administration of neoadjuvant therapy. In contrast to OPE, LPE had a significantly smaller operative time (319.3±129.3 minutes versus 417.3±155.0 minutes, t=4.531, P0.05). Conclusions In locally advanced rectal cancer tumors patients, LPE is associated with reduced operative time, less intraoperative blood loss, a lot fewer perioperative complications, and shorter hospital stay in contrast to OPE. Its safe and feasible without limiting oncological effect.With the development of existing medical methods, equipment and treatment principles, more and more medical centers commence to execute substantial resection for recurrent pelvic cancerous tumors or people that have multivisceral invasion. Exenteration may facilitate curative resection and increase the outcome of the patients. Therefore, pelvic exenteration has gradually get to be the standard of look after locally advanced pelvic malignancies. At present, pelvic exenteration leads to high intraoperative and postoperative problems and mortality, and therefore compromise the safety and lasting total well being Biopartitioning micellar chromatography . Cumulating evidences recommend Fingolimod concentration remnant cavity after exenteration might trigger the pathophysiological process and cause downstream complications which is often defined as empty pelvis problem. The literary works linked to vacant pelvic problem ended up being summarized, the possible reason behind bare pelvic problem had been analyzed. Following the pelvic exenteration, the closed pelvic residual hole formed continuous bad force ntestine in to the pelvic cavity by safeguarding the mesentery framework and restoring or rebuilding the mesentery morphology. With regards to of treatment steps, there was still too little standard therapy path for empty pelvic syndrome.Pelvic radiation damage can potentially include numerous pelvic body organs, and because of its progressive and irreversible nature, its late stage is complicated by fistulas, perforations, obstructions and other complications included multiple pelvic organs, which really affect the long-term success plus the well being of clients.