? Fields which have string values in XML are converted to properties in OWL. Example: The field Name which has a string value type becomes a datatype property hasName ? Ambiguous labels are unified. Example: The field Results is used in several different contexts, that is why we rename it to TreatmentResults, in the treatment www.selleckchem.com/products/Roscovitine.html group; ? Wherever possible, object type properties are introduced instead of datatype ones �C thus string values are replaced by named concepts. Example: In ToxML schema the field Sex is defined as a simple type of type string, which would be converted to property in direct conversion, but in OWL we introduce a new class Sex, thus creating an object property has Sex instead of a datatype one. ? Mapping to Organ ontology and study type classifications can be applied.

OpenToxipedia has been developed using the SMW. It was created manually by experts in the fields of in silico and experimental toxicology on the basis of known regulatory documents, glossaries, dictionaries and some primary publications. All registered members are welcome to add new entries, suggest definitions and edit the existing resource at http://www.opentoxipedia.org. OpenToxipedia is curated by toxicology experts within the OT community. The SMW was chosen for OpenToxipedia representation for the following main reasons: it enables automatic processing of the wiki knowledgebase and it gives a possibility for data transfer between RDF and SMW through SPARQL. SMW will facilitate the automatic data exchange between OpenToxipedia, the ontologies and OpenTox web services using RDF data.

The SMW is a collaborative system, supports versioning, RDF export, tools to lock pages by a curator (fixing a validated vocabulary) and the possibility to add annotation without changing the ontology or RDF information. Results and discussion Sub-ontology projects developed within the OpenTox project Up to now, six ontologies have been made available through the OT Collaborative Prot��g�� Server: ? Toxicological Endpoint ontology; ? Organs system and Effects ontology; ? ToxML ontology; ? OpenTox ontology, representing components of OpenTox web services, framework and Algorithm types; ? ToxLink (ToxCast [39] assays ontology); ? OpenToxipedia: SMW toxicology knowledge resource.

Toxicological Endpoint ontology The OT Toxicological Endpoint ontology contains five toxicity study types: carcinogenicity, in vitro bacterial mutagenicity, in vivo micronucleus mutagenicity, repeated dose toxicity (e.g., chronic, sub-chronic or sub-acute study types) and aquatic toxicity (see Figure Figure22). Figure 2 OpenTox toxicological ontology structure The purpose of Cilengitide this ontology is to enable the attributes of toxicological dataset entries to be associated with ontology concepts. The OT framework exposes REST web services, corresponding to common OT components.