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These studies showed that the therapeutic targeting of cyclin D1 and the road k Nnte to be an effective strategy for new therapeutic and roundtables. We have previously reported that cyclin D1-cyclin-dependent modulation and inhibit Ngigen kinases, which is either flavopiridol or a combination of N 4-OH Tam retinamide effective in inhibiting RT in vitro and in xenograft tumor models in vivo. The efficacy of flavopiridol and 4 HPR was correlated with the down modulation of cyclin D1 in the tumor xenograft. Flavopiridol is a CDK inhibitors are the first clinical trials. Although the first clinical trials were unsuccessful, the design of a novel schedule of administration on in vitro and in vivo pharmacokinetic modeling of flavopiridol, the effect of his showed promising activity in lymphatic leukemia Chemistry is based Of refractory chronic Ren. Phase I trials of flavopiridol in children have shown that its toxicity Tsprofil, pharmacokinetics and maximum tolerated dose who