H 1 h stirring. After GW786034 Pazopanib cooling, H2O was added and the precipitated white E or gray was through a pad of Celite, and w is deleted With big amounts of water, s. Min after removal of the gr Th part of the water by suction of air for 10 of the filter cake was YOUR BIDDING dissolved in CH2Cl2 St and the product was filtered and transferred into a 100 ml bottle, pear RMIG dried. Silica gel was added and the L Solvent was removed under reduced pressure. The rieself hige powder was transferred into an empty cartridge loaded CombiFlash fixed and the product purified by flash chromatography: 0-60, 30 min, 9 was isolated as a white solid he. 1H NMR: d7.80, 7.42, 7.29, 7.21, 6.85, 6.77, 6.75, 6.55, 3.98 3.44, 3.35 2.90, a, 33, 1.11, 0.97, 0.89 0.42 ppm, 13C NMR: d178.8, 151.2, 149.7, 147.6, 145.2, 138.7, 137, 3, 136.5, 130.0, 126.3, 125.7, 124.1, 123.7, 123.4, 46.8, 28.8, 28.6, 26.7, 23.5, 21.2, 20.9 ppm, the calculated elemental analysis. C35H45ClN2PdS for: C 62.96, H 6.79, N 4.20, found: C 62.72, H 6.63, N 3.94. ChloroACHTUNGTRENUNGpalladium: A 100 ml round bottom flask, PdACHTUNGTRENUNG2, acetanilide and a calculated eif-shaped magnetic stir bar in air. Anhydrous dioxane and TFA was added with stirring. The reaction mixture was heated at 70 8C for 2.5 h. Hot, greenish yellow L Solution was stirred with saline Solution diluted to 30 min. The precipitate formed was filtered and washed successively with H2O, Et2O and CH2Cl2. After drying, the cyclopalladated chloride acetanilide was obtained as a yellow solid canary. IPr Cl, K2CO3 and a magnetic stirrer eif RMIG were on this solid in a 50 ml bottle schchen Roundbottomed included in the air. CH3CN was added and the reaction mixture was kr Ftigem stirring for 2.5 h under reflux. The mixture was cooled to room temperature, and through a pad of Celite ample CH2Cl2. Ethyl acetate, gradient: 0 to 5, 30 min complex 11 2 was as a white solid after he flash chromatography to obtain L solvent B. 1H NMR: d9.72, 7.33, 7.20, 7.09 7.14, 6.77 6.85, 6.54 6.58, 6.35, 3.26, 3.06, 2 , 01, 1.39, 1.10, 0.97, 0.58 ppm, 13C NMR: d175.5, 166.9, 165.4, 147.8, 145.1, 141.6, 140, 1, 136.0, 134.8, 130.0, 127.4, 125.1, 124.2, 124.1, 124.1, 122.8, 117.8, 29.0, 28.5, calculated 26.7, 26.2, 23.1, 22.9, 21.9 ppm, HRMS. C35H44ON3 for 106Pd: 628.2514, found: 628.2526, C35H44ON3 108Pd: 630.2518, found 630.2517. NN N dimethylurea Stamml Solution A: Complex 11 was in a pear-given-shaped flask with a rubber stopper and the flask with Ar complex place filled sealed was, then dissolved in the volume st desired dry THF free oxygen. Stamml solution B NaOH in MeOH was gently stirred until the solution Aufl, then degassed by bubbling minutes of a gentle stream of Ar for 15 min. Reaction procedure: A pyrex glass tube was charged with a stir bar, N and S NN 鈥 鈥 dimethylurea acid otolylboronic. The tube was sealed with a septum and was filled with Ar An aliquot of the Stamml Solution A was then added and the mixture was stirred for 5 min. As N To search results, an aliquot of Stamml Solution B was added and the reaction mixture was stirred at the desired temperature for 18 h. The reactions were performed in duplicate and the mixtures were then quantitatively into a 100 ml flask, pear Shaped combined.