36 months and mortality differs by gender. Four groups were classified according to staining and immunostaining TUBB3 TUBB6. Groups 1, 2, 3, 4 and TUBB3 / TUBB6, TUBB3/TUBB6, TUBB3 / TUBB6 and TUBB3/TUBB6, respectively. There was a tendency, both antigens from coexpressed 60 and 59 Irinotecan Camptosar patients from Groups 1 and 4, respectively, so that statistically significant probability of expression of co. Kaplan-Meier curves for the four groups are presented in Fig. 1C and no statistically significant difference was COLUMNS in the patient population as a whole between the four groups of beautiful. After stratification by gender, the results were different. The behavior of curves in M Nnern was Similar to that in the general population observed no statistically significant differences between the four groups. In contrast, in women double negative patients very well and all survived, w While the mortality rate was in the other three sub-groups about 28%. The difference between double-negative patients compared to three other groups was statistically significant in women. To make an explanation Tion to find for these results, we performed a multivariate analysis to find the clinical factors with the expression of TUBB3 TUBB6 and cox1 inhibitor correlated in both sexes. We rank as variables by gender, clinical stage, age, histotype, TNM and analyzed values. A statistically significant correlation between the expression of only two TUBB3 and TUBB6 and the presence of metastases in women but not in M Found nnern. This finding suggests that the expression TUBB3 TUBB6 and events associated to metastasis only in women, suggesting the gender-specific regulation of expression of both TUBB3 and TUBB6.
Survive TUBB3 TUBB6 and freedom of expression in 22 colorectal cancer cell lines to better fully understand the regulation of specific sex this way, we used a panel of 22 colorectal cancer cell lines, the expression of both TUBB3 TUBB6 and analyzed in basal conditions and after serum withdrawal, is a stressor that can activate the path TUBB3 k. Nine cell lines were from female patients, w While 13 were m Nnlich. This analysis was performed on the gene and protein. Under basal conditions in women, there was a statistically significant correlation between the expression of TUBB3 and TUBB6. This correlation was not present at M Nnern cancer cell lines. When combined, resulted in the expression of TUBB3 no statistical significance MDV3100 between cell lines from M Nnchen and females, w In gene expression during TUBB6 nnern at M H Ago than with women. Subjection to serum deprivation was still an increase TUBB3 in the gene in cell lines that induce derived from women. Compared with the control group in a medium with serum erg Held complements, the average increase for TUBB3 cell lines 1.991.11 1.070.43 vs. women was recorded in M Nnerberufen cell lines, and the difference was statistically significant. TUBB6 also showed a trend in cell lines by serum deprivation in women compared to M Nnern to increased hen, But the difference was not statistically significant. At the protein level, we found the same trend. TUBB3 erh Hte expression significantly to serum withdrawal in cell lines of women, w While for male pattern cells were essentially the same.