1 c5 6 CK, CK 14, CK 17, p cadherin, caveolin 1, carbonic anhydrase IX gene, p63, and the pick-singer of the epidermal growth factor Similar their original cells in the normal breast tissue. Although it is MLN8054 not quite the same as breast cancer and triple-negative basal share many molecular characteristics with up to 70 concordance between the two subgroups. Interestingly, tumors associated with germline mutations in the BRCA 1 show are, presentation considerable overlaps in their clinical pr Molecular and tumors such as basal. BRCA 1 are usually associated with triple-negative tumors, and p With the heart of tea base like. Tumors on microarrays with a high proportion of express CK 5 6, 14, 17, p cadherin and EGFR Studies, the presentation, the Pr Histological and TNBC BLBC show that 90 of these tumors from Milchg length Derived and are often ph high histological grade and nuclear, high mitotic index, and aggressive Phenotypic properties have investigated associated.
Third Epidemiology Epidemiological studies show that women diagnosed with TNBC all manifest significant clinicopathological characteristics and risk factors compared to women with other subtypes of breast cancer. TNBC about 15 all Brustkrebsf Lle diagnosed, but in some Selected Hlten populations, the pr Prevalence h Time ago, for example, pr Menopausal African American patients and Spanish. Based on population studies based on multiple, women with TNBC on average younger t in the diagnosis and a disease with both ver Nderbaren and not ver Nderbaren risk factors, associated more tt age at menarche and first pregnancy, parity erh ht, reduced breastfeeding, h Heren BMI and lower socio economic status. 4th Patterns of recurrence and prognosis Bev POPULATION studies have basic Erh Increase the Todesf Lle in connection with triple-negative breast cancer patients are identified and different patterns of Fdbk Cases in this subgroup best CONFIRMS.
TNBC patients diagnosed with an h Here likelihood of recurrence was within the first three years after diagnosis and death from disease w During the first five years. In addition, the disease oncemetastatic, identifies patients with TNBC and experience BLBC time shorter survival time than patients with subtypes of tumors. Among TNBC patients relapse over 5 years are less hours Frequently and less than 10 years, the survival rates between different groups about equivalent. Women with TNBC h More often develop bone positively against visceral metastases in comparison to their counterparts in hormone receptor. In a multicenter study, which included large S 2000 patients with TNBC, Lin and his colleagues have shown that women with TNBC more likely to develop lung cancer 2.27, CI 95 were 1.50, 3.43, p = 0.0001 or brain metastases as their first site of recurrence. In comparison, the women a much lower risk of recurrence bone. Numerous studies have demonstrated an increased Hte rate of CNS metastases in women