mVI significantly decreased LT benefit only in patients staged I-II with MELD < 10; this subgroup had already a negative benefit independently from mVI, however. Staging significantly increased LT benefit only in patients with MELD > 10 with a stage III tumor; this subgroup had an unacceptable 5-year post-LT survival (<50%), however. Conclusion. From a transplant benefit perspective, MELD score is the only variable with the potential to Opaganib nmr influence the therapeutic decision between LT and HR. Disclosures: Umberto Cillo – Grant/Research Support: Novartis, Bayer,

Astellas The following people have nothing to disclose: Alessandro Vitale, Teh Ia Huo, Alessandro Cucchetti, Antonio Daniele Pinna, Yun Hsuan Lee Background The natural history of donor recovery after hepa-tectomy remained unclear. Long-term data on donor physiological alterations remained scarce. Platelet count reflected the joint effect of hemostasis, thrombopoeisis and splenic sequestration.

Its persistent decrease after donor hepatectomy provided insight into the donor recovery process. Our study aims to investigate for the clinical factors associated with the persistently decreased platelet count after living donor right hepatectomy. Methodology From October 2003 to December 2009, 1 75 right liver living donor liver transplants BMS-777607 datasheet were performed in our center. Liver volume, graft weight and laboratory parameters up to 2 years follow-up were analyzed. Donors are grouped into

those with >20% drop in platelet count (Group A) and < 20% drop (Group B)Factors associated with platelet drop are analyzed. Results Mean age of the donors were 34.4 years. 67% of the donors were female. The mean selleck compound total liver volume and right liver graft volume were 11 10.6 ± 178.4 cc and 710.9 ± 125.4 cc respectively. The platelet level at 2 years was significantly lower than pre-operative (212.9 ± 47.8 x 10^9/L vs 259.3 ± 54.8 x 10^9/L, p < 0.001). The mean percentage drop in platelet level was 17.1 ± 14 %. With comparable demographics, donors in Group A were significantly different to Group B with regard to: percentage remnant volume (p = 0.012), graft weight-to-liver volume ratio (p < 0.001) and peak post-operative ALT level (p = 0.067). The percentage drop in platelet count at 2 years was correlated to the graft weight-to-liver volume ratio with a R^2 = 0.046. Summary Our findings signified that after hepatectomy, subclinical hyperslenism may persist in the donors. Correlation between extend of hepatectomy and magnitude of drop in platelet count at 2 years was first shown. Disclosures: The following people have nothing to disclose: Shi Lam, See-Ching Chan Background: Several studies have investigated liver stiffness by transient elastography measured by fibroscan in healthy populations, but very few included subjects with liver biopsy. The stiffness of the liver with “”normal”" histology needs further assessment.