important in some stages of pulp repair NVP-LAQ824 HDAC inhibitor and differentiation. Future studies are necessary to demonstrate the functional activity of t 1 pf of TGF Control and regulation of Runx 2 and ALP in the cells of the pulp. Curcumin is a polyphenolic natural product made from turmeric, a powder produced from the rhizome of the plant Curcuma longa isolated. Curcumin has been shown to be a wide range of medical services in the human Produces body and proved to be a potent therapeutic agent against various pathological processes in humans. Over the last few years have shown that curcumin, a potential anti-cancer agent against various human tumors both in vitro and in vivo and in clinical trials. Pr Clinical studies have shown that curcumin up and st Ren virtually every important phase of carcinogenesis, including cell proliferation, survival, angiogenesis and metastasis.
The mechanisms underlying the anti-cancer activity Th of curcumin have been extensively studied. Several signaling molecules are identified which are aligned by curcumin confinement Lich 5 alpha dht ornithine decarboxylase, p53, c-myc, cyclin D1, nuclear factor jB, the activator protein 1 tyrosine kinase, Akt, protein kinase C and mammalian target of rapamycin that. Curcumin, the dependent apoptosis in p53 Ngiger and independent Ngiger in a variety of tumor cell lines confinement Lich those with breast cancer, prostate cancer, cancer of the c Lon, kidney cancer, liver cancer, leukemia Anemia, lymphoma, basal cell carcinoma, melanoma and rhabdomyosarcoma.
It was reported that curcumin, the apoptosis by p53 dependent Independent Induction of p53 and Bax induce the expression of p21Cip1 in some tumor cell lines, such as hepatoblastoma, neuroblastoma, glioma, melanoma and breast cancer cells. On the other hand, was also found that curcumin, the p53-dependent apoptosis by Independent down-regulation of p53 in breast cancer and lymphoma, as will induce, for example in B-cell lymphoma cells curcumin reduces p53 expression and survival proteins including normal pro Egr 1, c-myc and Bcl XL. In cancer cells, c Lon, curcumin interrupted the conformation of the protein p53 tumor suppressor functions that are required, including normal serine phosphorylation, DNA binding, transactivation of p53-p53-mediated cellular response cycle Re arrest. The discovery of p53 activity T reduced by curcumin was also seen in normal thymocytes and myeloid leukemia Mie cells Of where the curcumin induces p53 degradation.
Mechanically, found curcumin promotes the dissociation of NADH: quinone oxidoreductase, a p53 complex in suppressing the activity of its NQO1, a flavoenzyme that binds and stabilizes wild-type p53. Therefore, the molecular mechanism of apoptosis induction by p53 dependent curcumin Ngig dependent on cell type be Ngig appear Despite these findings, the molecular mechanism by which curcumin induces p53-independent Independent Apoptosis not well understood. Increasing evidence has implicated members of the family of protein kinases play a mitogenactivated r Essential in p53-independent Independent apoptosis. Mammalian cells in S, There are at least three different groups of MAPK, extracellular Re-regulated kinase protein signal including normal 1/2, c-Jun N terminal kinase and p38 MAPK. ERK1 / 2 is used primarily by growth factors and ma Triser cell proliferation, differentiation and development activated