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“Objective: To describe the various anesthetic techniques used for surgical closure of PDA in premature infants at the Montreal Children’s Hospital and assess their impact on postoperative outcome.\n\nStudy Design: The charts of all preterms who underwent PDA Selleckchem LCL161 ligation during a 21-month period were reviewed for preoperative status, intraoperative anesthetic management and postoperative outcome. We determined the associations between independent variables and two postoperative outcome variables: unstable postoperative respiratory

course (UPRC) and hypotension.\n\nResult: The mean weight at surgery of the 33 infants was 1.031 +/- 0.29 kg. All infants, but one, received intraoperative opioids. Eight patients presented UPRC. Mean fentanyl doses were 5.3 +/- 2.6 mcg kg(-1) for patients with UPRC vs 22.6 +/- 16.6 mcg kg(-1) for patients without UPRC (P = 0.004). Applying the receiver-operator characteristic curve (ROC), 10.5 mcg kg(-1) of fentanyl Selleck Buparlisib was established as the dose that discriminated and identified patients who experienced UPRC. The postnatal and postmenstrual age of the patient, birthweight, current weight, ventilator settings preoperatively, previous courses of indomethacin, sex and preoperative creatinine, were not correlated with the dose of fentanyl equivalent used. Logistic regression did not show a relationship between any of the

previously mentioned factors and receiving a fentanyl equivalent of > 10.5 mcg kg(-1). The only factor associated with the total fentanyl equivalent dose (as a continuous variable) or receiving < 10.5 mcg kg(-1) (as a dichotomous

variable) was the identity of the anesthetist involved, P < 0.001.\n\nConclusion: We conclude that the use of at least 10.5 mcg kg(-1) of fentanyl equivalent as a component of the anesthetic regimen for surgical closure of a PDA in premature infants, avoids an unstable postoperative respiratory course. Journal of Perinatology (2010) 30, 677-682; doi: 10.1038/jp.2010.24; published online 18 March 2010″
“Purpose Panic Disorder (PD) is a classic example of a disease where symptom remission may be achieved, yet patient quality of life (QOL) remains low, providing further support for the need to measure QOL as an additional outcome P5091 in patient care. The objectives of this review are to examine the substantial QOL impairments in PD and to determine whether modern treatments for PD, which have been proven to achieve symptom remission, have been shown to restore QOL.\n\nMethods We identified studies on QOL in PD from 1980 to 2010 by searching MEDLINE, PsycINFO, and PubMed databases.\n\nResults The literature reveals substantial QOL impairments in PD, often resulting in poor sense of health, frequent utilization of medical services, occupational deficiency, financial dependency, and marital strife.