Carboplatin to the peptidomimetic lactam antibiotics. Keywords amlodipi lactam antibioti interacti bioavailabili healthy volunteers Many lactam antibiotics are transported by the intestinal peptide carriermediated transport system that consists of the H /oligopeptide transport PEP . Probably by stimulating PEP nifedipi a dihydropyridine Ca antagoni may have the potential to produce clinically significant enhancement of bioavailability of several lactam antibioti such as cephalex amoxicill and cefixime. Chemical amlodipine belongs to the same family of dihydropyridine derivatives as nifedipine. It has physicochemical properties similar to nifedipine as well. According by mechanisms similar to nifedipi AML may reasonably be expected to enhance some lactam bioavailability.
There is the potential for clinical benefit if indeed AML enhances lactam bioavailability. Furthermo we hypothesize that the effect may vary in In this w crossover study in 4 healthy voluntee we investigated the effects of AML on the bioavailability of different lactam antibiotics. Shikimate inhibitor We also determined whether this interacti if a is related to the structural characterization of lactam antibiotics. Materials and Methods Participants . Twentyfour healthy volunteers between ages 5 and 5 years and with body mass indexes between 9 and 5 kg/m were eligible for enrollment after informed consent forms were signed. All participants were determined to be in good health on the basis of medical histo results of physical examinatio routine laboratory tes and electrocardiogram findings.
kinds of lactam antibiotics because some of them are not substrates of PEP . As a resu our study involved Xijing Hospital of the Fourth Military Medical Universi Xi China kinds of lactam antibiotics: cephalexi a peptidomimeticpound almost exclusively EPO906 152044547 transported by the peptide transporter buy Celastrol with practically no additional passive entry in the mammalian intesti and cefuroxime axeti the prodrug of cefuroxi which is deesterified in the intestinal mucosa and absorbed into the bloodstream without involvement of peptide transporters. These authors contributed equally to thepletion of this study and the writing of this article. Submitted for publication 8Aug; accepted 2Dec Corresponding Author: AiDong W Department of Pharma Xijing Hospital of the Fourth Military Medical Universi ChangLe West Rd 5, Xian 2, China adwen hotmail Downloaded from jcp.
sagepub at Bobst Libra New York University on March 7, They were excluded from study participation if they had donated blood or had participated in a clinical trial with an investigational zygote drug within 0 days of study initiation. Regular heavy drinke smokers of more than 0 cigarettes per d and those with a body weight differing by more than 0 from their ideal weight were also excluded. Study Design . This was an op randomiz singledo w crossover study in 4 healthy volunteers. The study was conducted in accordance with Good Clinical Practice guidelines and the Declaration of Helsinki. The protocol was approved by the Institutional Review Board of Xijing Hospit Xi China. Participants were randomized to receive each of dosing regimens separated by a washout period of 4 days. The regimens were as follows: LEX mg alone;