Stool consistency (watery, soft, or firm) and its frequency (in 2

Stool consistency (watery, soft, or firm) and its frequency (in 24 h) were

checked by the patients’ mothers and reevaluated and recorded by trained pediatrics residents. The study protocol was approved by the Ethics Committee of Urmia University of Medical Sciences. Statistical Analysis The results are reported as mean ± standard deviation (SD) for the quantitative variables and percentages for the categorical variables. The groups were compared using the Student t test for the continuous variables and the chi-square test (or the Fisher exact test, if required) for the categorical variables. Statistical significance was based on two-sided design-based tests, evaluated at 0.05 level Inhibitors,research,lifescience,medical of significance. All the statistical analyses were performed using SPSS version 16 (SPSS Inc., Chicago, IL, USA) for Windows. Results A total number of 379 cAMP inhibitor patients (188 in the intervention group and 191 in the control group) were assessed after the application of the Inhibitors,research,lifescience,medical inclusion and exclusion

criteria. Twenty-one persons in the treatment group (14 due to vomiting, 3 due to report of WBC/RBC in stool, 2 due to later cancellation of participation, and 2 due to report of significant steatorrhea Inhibitors,research,lifescience,medical in stool examination) and 15 in the control group (9 due to vomiting, 5 due to report of WBC/RBC in stool, and 1 due to later cancellation of participation) were excluded after the random allocation of the study population to the two groups. Ten patients in the intervention group (9 due to intolerance and 1 due

to early discharge because of personal consent) and 13 in the control group (8 due to intolerance, 3 due to early discharge [personal consent], Inhibitors,research,lifescience,medical and 2 due to Inhibitors,research,lifescience,medical late onset fever) were lost to follow-up. Finally, 157 patients (59.2% boys, mean age=18.7±9.7 months) were classified in the treatment group; in addition, a control group of 163 patients (52.1% boys, mean age=17.0±8.0 months) was recruited. Table 1 summarizes the patients’ baseline and demographic characteristics in each group. There were no significant MTMR9 differences in terms of the initial profiles between the two groups. Table 1 Patients’ demographic characteristics at enrollment As is shown in table 2, the patients treated with zinc supplements had shorter hospital stays (2.5±0.7 days) than those receiving routine care in the placebo group (3.3±0.8 days) (P=0.001). In the intervention group, the mean diarrhea frequency was lower than that of the control group (4.5±2.3 vs. 5.2±2.1; P=0.004). Stool consistency exhibited better improvement in the intervention group than in the placebo group (P=0.017, P=0.001, and P=0.06 for post-treatment days one, two, and three, respectively), and the mean patients’ weight at discharge time was non-significantly greater in the intervention group than in the placebo group (10.5±3.1 vs. 10.1±2.3 kg; P=0.135).

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