Ion of interest, it is important to not only the most important compounds, but their 13 S-dihydro metabolites which are not only pharmacologically active but also have to determine with anthracycline-Kardiotoxizit Ts Vincristine leurocristine associated side effects. Aglycones and glucuronides can be measured, but are not held toxicological relevance. However, it ensured that these metabolites are not important in the determination of the compounds or their metabolites st Ren. HNT Of the 35 publications mentioned in this aper U, 12, a single lead compound to quantify. Others identify a lead compound and its reduced metabolites, sometimes with additional keeping metabolites. The method can be applied individually to each of the four pairs. Four methods have been developed to simultaneously determine k Nnten two or more lead compounds, alone or together with their metabolites. When the alpha phase after administration of intravenous Water bolus in the study and undiluted samples to be measured must be included, one must keep in mind that the plasma concentrations of the most important connections are ng / ml to 10 000 m Possible. If not, the plasma concentrations were 1000 ng / ml or less. The lower detection limits in the low ng / ml should hrleisten detection of up to 24 hours or more after administration to weight. For a reduced metabolite, Similar LIQ and an upper limit of quantification of 250 ng / ml in the plasma is recommended. In addition to determining the limit of quantification, validation of analytical methods required to determine the pharmacokinetics of anthracyclines in clinical studies that parameters such as Pr Precision and accuracy to the acceptance criteria, and meet in front of established parameters such as selectivity t have stability t, linearity t and recovery evaluated. The diagnosis of acute leukemia Chemistry based on a combined approach Including Lich morphology Immunph phenotype, karyotype and specific molecular genetic markers. This approach can be most acute leukemia Premiums clearly be attributed myelo Of, B-or T-lymphocyte lines Of.
In a small subset of acute leukemia Mie S, but the line is hard to classify. The diagnosis of acute leukemia Chemistry mixed Ph genotype was on the rating system of the Europ European Group for the immunological classification of acute leukemia chemistry is based and a proportion of 1% to 5% of acute leukemia mie s Recently, the classification of the World Health Organization, a simple algorithm for defining MPAL proposed. Acute leukemia chemistry secondary Ren to previous treatment, especially myeloid leukemia is chemistry acute and therapy-related acute leukemia chemistry lymphoma is much rarer than therapy related AML. The treatment of acute leukemia Chemistry show related mixed Ph genotype is extremely rare, and only two of these F cases have been reported so far. We report a new case of t AL t and shows mixed Ph Genotype, which occurred rmutter after chemo-and radiotherapy for cancer of the building. Second Case A 49-j Hrige woman with palpable mass in his neck and back pr Formononetin Presents. Tomography revealed a solid mass of 1.6 cm infiltration of the left submandibular gland and a mass of 6 cm soft tissue with the left posterior abdominal wall. Seven years earlier she had undergone a radical hysterectomy with bilateral pelvic lymphadenectomy for endometrial adenocarcinoma. After surgery she had back U 3 cycles of systemic.