Contribute to the induction of brain responses to disease control Strip over transcriptional regulation of inflammatory target genes. Spatiotemporal Stimulation of signaling pathways in the brain by LPS or cytokines that are involved in this reaction activates the transcription factors nuclear factor involved JB, signal transduction and activator of transcription IL6 and NF. The target genes of these transcription factors comprising the H Height of the two boundary lines functionally enzymes in the pathway of synthesis of prostaglandin E2 n, Coupled namely cyclooxygenase-2 and PGE synthase is microsomal. PGE2 is known as a very central role in the generation of terminal fever. Zus Tzlich to these inflammatory mediators, LPS is also known that oxidative stress in the hen brain obtained. So far it has even been suggested that oxidative stress in the induction of fever after LPS stimulation device To do th. Parthenolide is a sesquiterpene lactone from Mexican Indian medicinal plants, and feverfew, to a variety of natural products, the potential for their anti-inflammatory and antioxidant properties have been used to derive go Rt. It is important due to its inhibitory properties and lipophilic character, a permeability t BBB f Promoted is parthenolide as effective in the treatment of migraine Ne models and occurs to a therapeutic agent for treating cancer, including normal glioblastomas . In vitro Gemcitabine Cancer studies have shown that parthenolide inhibits NFjB way by the kinase inhibitor jB activation or degradation of IjBa. Among other effects, it was reported that parthenolide inhibit STAT3. His influence on NF IL6 yet to be determined. The r The backbone of NFjB in the fever is due to the fact that mice M, Which supports NFjB not develop fever in response to LPS or bacterial DNA, another stimulant of innate immunity T. However, Kozak et al. showed no attenuated want to LPS against plague in mice by pretreatment with parthenolide M induced and showed no effect of parthenolide on the levels of plasma cytokines induced by LPS, as previously shown by others.
However, in vitro experiments have shown that reduced significantly from other parthenolide treatment LPS-induced TNF and IL-6 and COX2 and mPGES expression of multiple populations of macrophages. LPS, the activity of t of these transcription factors Changed is induced known for Varespladib the main effects mediated by nuclear factor jB signaling and oxidative stress. LPS is therefore to examine a good model for the effect of parthenolide on the brain and the periphery in vivo. The molecular mechanisms of parthenolide acts on the brain in vivo w During infection and inflammation are yet to be determined, ob Thus, the aim of this study, the effects of IP injected with parthenolide on LPS-induced fever and associated inflammatory diseases of the brain and oxidative stress responses to study in rats. LPS stimulates the systemic reaction by measuring the plasma IL-6 and TNF bioactivity was t monitored. As Ma was in the inflammatory response of the brain, activation of inflammatory cells through hypothalamic by RT-PCR analysis of the IJB suppressor of cytokine signaling 3, the serine / threonine kinase hnlichen determined protein and mRNA expression of NF IL6 Trib1. RT-PCR measurements were combined.