Erh hen Damage, inhibit survival signaling pro, inhibit the repair of induced DNA-Sch Ending, potentiate the pro-apoptotic factors, thus the antioxidant potential, hen to the level of ROS in the cell increased. It k Nnte act by suppression of intracellular GSH or other k Rpereigene substances or Erh Hung radioprotective accumulation in the cells used. Below are some of the secondary Higher plants materials, widely studied for their r The radiosensitization of cancer cells. 5.2.1. Curcumin Curcumin, the yellow polyphenolic compound that was isolated from the rhizome of the plant Curcuma longa studied extensively over the last five decades for his chemopr Preventive and anti-cancer effect. In vitro and in vivo activity have been different Th, as anti-inflammatory cytokine release, antioxidant, immunomodulating per apoptotic process, and Ivacaftor VX-770 demonstrated anti-angiogenic properties of curcumin. The anti-cancer potential of curcumin is due to its F Ability to suppress or down-regulated transcription factors such as NF-kB, AP 1 and Egr first Its anti-inflammatory and anti-angiogenic effects are caused by the low regulation of the expression of COX-2, LOX, NOS, MMP 9 and uPA. Curcumin is also known to negatively regulate the growth factor receptors, including normal EGFR and HER2. Because of all these properties is curcumin as m Glicher adjuvant chemotherapy and radiotherapy. Pretreatment of the two cell lines of Geb Rmutterhalskrebs, HeLa and Siha, with curcumin before treatment with IR resulted in a significant dose- Ngigen radiosensitization of these cells.
However, curcumin was able to normal fibroblasts radiosensitize diplomatic Of people. Curcumin, Changed not alter AKT or NF-kB, which are involved in the rule in the development of radioresistance, but by a significant increase in the production of reactive oxygen species, which also leads to extracellular Re signal-regulated supports a half-kinase activation. Therefore, it was suggested by an increased radiosensitization Hte production of ROS by inducing the oxidizing agent per hour at Higher doses. Curcumin shows the radiosensitization by the inhibition against squamous cell carcinoma of the antioxidant enzyme thioredoxin reductase first MM curcumin at a dose of 2 and 4 induced a significant inhibition of Klonogenizit t compared to radiation alone in p53-deficient cells of prostate cancer. Pre-treatment of ovarian cancer cells sensitized with curcumin cells to the therapeutic radiation dose. Pretreated cells, inhibition of colony formation than those treated with curcumin or radiation. Radiation exerts an anti-angiogenic effect on tumors, inhibition of endothelial cell proliferation and survival in the tumor microvasculature. However, the damages caused to induce by low levels of radiation has a paradoxical effect, stimulates the survival of endothelial cells. Low-level radiation has been demonstrated that NF-kB and phosphatidylinositol-3 kinase / AKT, a renewed entry of the cell cycle and survival of cells in human mikrovaskul Activate Ren endothelial cells is involved. The aim of the PI3K/AKT downstream mammalian target of rapamycin, the endothelial proliferation and angiogenesis Posts Gt Exposure of HMEC to a low level of radiation-induced Akt and mTOR phosphorylation was inhibited by curcumin.