Metastasis is the major obstacle in the treatment of malig nant c

Metastasis is the major obstacle in the treatment of malig nant cancer and it accounts for more than 90% of cancer related mortality. selleck chem CHIR99021 Since gastric cancer is the second most lethal cancer worldwide, the underlying molecu lar mechanisms responsible for gastric cancer metastasis need to be elucidated. Nuclear factor ��B is a family of signal responsive transcription factors that includes RelA p65, RelB, c Rel, NF ��B1 p50 and NF ��B2 Inhibitors,Modulators,Libraries p52. NF ��B exists in an in active form in the cytoplasm because of its interaction with the inhibitory protein, I��B. After activation of I��B kinases, I��Bs become phosphorylated, ubi quitinated and degradaded by proteasomes, which allows NF ��B to translocate to the nucleus, where it can activate or repress target genes.

With respect to gastric cancer, NF ��B is one of the most well studied transcription fac tors, and is known to be activated by various factors, including cytokines, growth factors, Toll like receptor signaling and many other pathways of microbial recognition. NF ��B activation has been frequently observed Inhibitors,Modulators,Libraries in both gastric cancer cells and tumor infiltrating lymphocytes. In addition, down regulation of NF ��B has been shown to suppress cell migration and invasion in gastric cancer cells in vitro. Thus, modulation of the NF ��B pathway might be a promising therapeutic target for gastric cancer metas tasis. However, the downstream mediators of NF ��B induced metastasis in gastric cancer cells remain unclear. Signal transducers and activators of transcription 3 belongs to the STAT family of signal responsive transcription factors.

The inactive form of STAT3 in the cytoplasm of non stimulated cells is activated by cytokines, growth factors and oncogenic proteins through sequential Batimastat phosphorylation of tyrosine 705 and serine 727. Like NF ��B, constitutive activation of STAT3 has been shown to contribute to the progression of gastric can cer, including proliferation, apoptosis, angiogenesis and metastasis. However, STAT3 showed differential roles in gastric cancer cell metastasis depending on the upstream regulator of STAT3 activation. Previously, NF ��B activation in human cancers has been reported Inhibitors,Modulators,Libraries to be positively or negatively correlated with STAT3 activation in the control of tumorigenesis, tumor growth and angiogenesis. STAT3 activation increased NF ��B activation and tumor growth derived from cervical cancer cells or glioblastoma cells.

STAT3 also maintains NF ��B activation and reten tion in the nucleus in melanoma cells and prostate cancer cells. In addition, NF ��B activation increased STAT3 activation through up regulation of interleukin 6 in melanoma cells. On the other hand, a positive crosstalk between NF ��B and STAT3 was found in B cell lymphoma, which increased Inhibitors,Modulators,Libraries cell proliferation and decreased mostly apoptosis.

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