Published by Elsevier Ltd. All rights reserved.”
“In this study, two new compounds and six known compounds were isolated from the aerial parts of Pteris semipinnata. The chemical structures of these

two new compounds selleck inhibitor were elucidated as 6,11-dihydroxy-15-oxo-ent-kaur-16-en-19-oic acid (1) and 7,11-dihydroxy-15-oxo-ent-kaur-16-en-19-oic acid (2) by the extensive spectral methods including 2D NMR and HR-MS techniques.”
“The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (n) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer.

The in vitro dissolution rate constant, dissolution half-life and pharmacokinetic parameters (C(max), t(max), AUC((s)), t(1/2), K(el), and MRT) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between

per cent of drug absorbed from patches vs. C(max) and AUC((s)). A good correlation was also observed when per cent drug released was correlated with Selinexor price the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery.”
“The paper examines a case of cross-border reproductive care that happens in reverse by looking at Israeli-Romanian transnational ova traffic. The state of Israel claims to have the most IVF clinics per capita in the world, some of the highest success rates in the use of assisted reproductive technology, very liberal regulation of these technologies and the most heavily subsidized IVF in the world. This support and the government’s demographic

BAY 73-4506 policies are designed to encourage the growth of the Jewish population in its demographic race against Palestinians. Yet transnational egg donation is very costly and reimbursement to patients a slow and involved process. Hence, while transnational ova donation is increasing in Israel, only a few can afford to participate in this border crossing. Further, new laws are meant to forbid cross-religious donation in Israel, hardening the borders of the Jewish State. Romanian ova donors are part of the global majority, exploited by markets’ incursions into new niches in bodies. The history of Romanian oppression of women’s reproduction makes today’s women willing to undergo invasive treatment for very little compensation, even when there is the possibility of injury. This paper documents reverse traffic reproduction, which maintains, rather than addresses, inequalities. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd.

The aim of this study was to validate all measurement modes of the Nissei DM-3000 device according to the European Society of Hypertension (ESH) protocol, as well as to develop and validate a ‘blinded’ auscultatory measurement mode. Different measurement modes were developed and evaluated in separate studies. Nine sequential same-arm BP measurements were taken alternating between simultaneous mercury sphygmomanometer readings and the device. The latter seven measurements were analysed according to the requirements

of the ESH protocol. All measurement modes of the device passed the ESH protocol. The blinded mode achieved the best results with a mean difference +/- s.d. of -0.1 +/- 2.6 and 0.04 +/- 2.4 mm Hg for systolic BP (SBP) and diastolic BP (DBP), respectively. The most accurate auscultatory measurement results

were obtained with a deflation rate Avapritinib of 2.5 mm Hg s(-1) achieving a mean difference +/- s.d. of -0.6 +/- 4.4 (for SBP) and -1.4 +/- 2.8 mm Hg (for DBP). The automated mode achieved a mean difference +/- s.d. of -0.8 +/- 6.0 (SBP) and 0.8 +/- 4.8 mm Hg (DBP). The Nissei DM-3000 device is a suitable replacement for the mercury sphygmomanometer. Y-27632 cost Journal of Human Hypertension (2010) 24, 609-616; doi:10.1038/jhh.2009.113; published online 28 January 2010″
“A step-graded AlxGa1-xN electron blocking layer (EBL) is studied on InGaN-based laser diodes (LDs). Its efficacy on device performance is investigated with respect to stimulated emission properties, internal quantum efficiency, internal loss, and temperature-dependent characteristics. When compared Bromosporine concentration to a LD structure

with an abrupt Al0.18Ga0.82N EBL design, the LD with the step-graded AlxGa1-xN EBL design demonstrates lower threshold current density and higher slope efficiency. The threshold current density is reduced from 4.6 kA/cm(2) to 2.5 kA/cm(2) under pulsed-current operation and the corresponding slope efficiency is increased from 0.72 W/A to 1.03 W/A. The insertion of the step-graded AlxGa1-xN EBL leads to a dramatic enhancement in internal quantum efficiency from 0.60 to 0.92, while internal loss keeps at 9 similar to 10 cm(-1). The temperature-dependent measurement also shows that the step-graded AlxGa1-xN EBL can improve the thermal stability with reduced red-shift from 0.05 nm/K to 0.034 nm/K. This simple yet efficient structural design change provides an effective way to achieve high-performance InGaN-based LDs with higher optical-output power and lower electric-power consumption. (C) 2011 American Institute of Physics. [doi:10.1063/1.3581080]“
“The full-length cDNA of a cyclophilin-like gene was cloned from Gossypium hirsutum using rapid amplification of cDNA ends and was designated as GhCyp1, a member of the immunophilin protein family. GhCyp1 expression level was higher in roots and stems than in other tissues of cotton, as determined by real-time reverse transcription polymerase chain reaction (RT-PCR).

The storage modulus ratios obtained from the dynamic mechanical analyses data of the crosslinked polymers were also high compared to that of the linear polyurethane. As a result, crosslinked polymers showed better shape-memory properties compared to the linear polyurethanes. Also, the that incorporation of the hyperbranched polymer as a crosslinker into the polyurethane chain improved the thermal and mechanical properties of the polymer. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 725-734, 2011″
“The precessional magnetization dynamics of high quality epitaxial magnetite (Fe3O4)

thin films growth on MgO are investigated by inductive magnetization dynamic measurements in time and frequency domain. An upper bound for the intrinsic Gilbert damping parameter of alpha(0) =0.037 +/- 0.001 is derived, which is significantly lower than previously reported for epitaxial Fe3O4 on GaAs. With increasing film thickness RepSox cell line from 5 up to 100 nm

a strong increase in the effective damping up to 0.2 is observed which cannot be explained by simple nonuniform spin wave excitations. Possible origins of this effect are discussed. (C) 2011 American Institute of Physics. [doi:10.1063/1.3531989]“
“Acrylic fibers are synthetic fibers with wide applications. A couple of methods can be utilized in their manufacture, one of which is the dry Stattic spinning process. The parameters in this method have nonlinear relationships, making the process very complex. To the best of the authors’ knowledge, no comprehensive study has yet been Talazoparib supplier conducted on the optimization of acrylic dry spinning production using computer algorithms, in this study, such parameters as extruder temperature in and around the head, solution viscosity, water content in the solution, formic acid content of the solution, and the retention time of the solution in the reactor were measured in an attempt to predict the behavior of the dry

spinning process. The color index of the manufactured fibers was used as an indicator of production quality and statistical methods were employed to determine the parameters affecting the process. An artificial neural network (ANN) using the back propagation training algorithm was then designed to predict the color index. ANN parameters including the number of hidden layers, number of neurons in each layer, adaptive learning rate, activation functions, number of max fail epochs, validation and test data were optimized using a genetic algorithm (GA). The trial and error method was used to optimize the GA parameters like population size, number of generations, crossover or mutation rates, and various selection functions. Finally, an ANN with a high accuracy was designed to predict the behavior of the dry spinning process. This method is capable of preventing the manufacturing of undesired fibers. (C) 2010 Wiley Periodicals, Inc.

Fifty-one cases of LA have been reported and are reviewed in detail.

Results: Clinically, LA could present as monoarthritis or oligoarthritis. INCB018424 in vivo The lateral compartment of the knee is the most common site of involvement. Several cases were reported as a comorbidity of inflammatory diseases, but were not improved by anti-inflammatory therapy. Most patients were diagnosed by classic MRI and biopsy findings. The lesions can be managed by open or arthroscopic surgery, but a minority of the cases may have reoccurrence

in the same or opposite joint.

Conclusions: LA is a very rare lesion of the synovial and bursal tissue with an unknown etiology. It is considered to be a benign proliferation of the synovial fat associated with trauma, degenerative or inflammatory conditions. LA should be considered as a secondary or comorbid condition in inflammatory arthropathies if other joints respond well to intensive therapy and one or more do not. (C) 2013 Elsevier Inc. All rights reserved.”
“A noniterative GSK461364 nmr identification technique is developed for the computation of parameters of the energetic model of hysteresis. Due to the relatively simple form of model equations, we are able to identify the subset of physical

parameters (e.g., coercive fields, remnant magnetizations, differential susceptibilities, etc.) that can be described by the model. This allows us to find necessary and sufficient conditions under which the energetic model can be applied to a magnetic material with given physical characteristics, in this way establishing the limits of applicability of the model. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3063668]“
“Objectives: Hydroxychloroquine (HCQ) is a widely used medication for the treatment of rheumatoid arthritis and systemic lupus erythematosus. An increasing body of evidence supports actions of this drug that are not directly related to its immunosuppressive or anti-rheumatic properties. The objective of this systematic review is to characterize the spectrum of conditions that

might be responsive to treatment with HCQ.

Methods: PubMed was searched using the MeSH for HCQ with relevant subheadings and the limits of human topics and English language. Four-hundred and fifty-six abstracts from this search GSK126 ic50 were examined individually to exclude those that were not focused on the objectives of this review. The resulting 76 articles were grouped according to topic areas and reviewed in detail.

Results: HCQ has been reported to have therapeutic effects in a wide array of conditions, including diabetes mellitus, dyslipidemias, coagulopathies, infectious diseases and malignancies. Mechanisms of action responsible for these effects likely include altered signaling through cellular receptors, postglycosylation modifications of infectious agents, changes in levels of inflammatory mediators and inhibition of autophagy.

Above T-N, it exhibits a cubic (Fd (3) over barm) structure. On lowering the temperature below T-N, weak superlattice reflections are observed

indicating the onset of AFM ordering accompanied by a rhombohedral distortion. The crystal structure in the AFM state is refined in R (3) over barm space group. (C) 2011 American Institute of Physics. GS-4997 [doi: 10.1063/1.3556917]“
“Background: During early postnatal development, the nervous system accretes docosahexaenoic acid (DHA; 22:6n-3), a highly unsaturated n-3 (omega-3) fatty acid (FA) used in the formation of neural cell membranes. DHA, which is present in human breast milk, may also be biosynthesized from n-3 FAs such as 18:3n-3 [alpha-linolenic acid (ALA)] or 20: 5n-3 [eicosapentaenoic acid (EPA)].

An important concern is to what extent these precursors can supply DHA to the developing infant.

Objective: We analyzed measurements of fractional percentages of plasma H-2(5)-ALA and C-13-U-EPA directed toward the synthesis of labeled 22: 6n-3 in 11 newborn infants by using compartmental modeling procedures.

Design: One-week-old infants received doses of H-2(5)-ALA and (CU)-C-13-EPA ethyl esters enterally. We drew blood from the infants periodically and analyzed the plasma for endogenous and labeled n-3 FAs. From the time-course concentrations of the labeled FAs, we determined rate constant coefficients, fractional synthetic rates, and plasma turnover rates of n-3 FAs.

Results: In infants, approximate to 0.04% of the H-2(5)-ALA Nutlin-3a price dose converted to plasma H-2(5)-EPA. Plasma H-2(5)-EPA and H-2(5)-22: 5n-3 [docosapentaenoic acid (DPA)] efficiently converted to H-2(5)-DPA and (2)H(5)DHA, respectively. The

percentage of plasma C-13-U-EPA directed toward the synthesis of C-13-DHA was lower than the percentage of plasma H-2(5)-EPA that originated from H-2(5)-ALA.

Conclusions: Endogenously synthesized EPA was efficiently converted to DHA. In comparison, Selleck ITF2357 preformed EPA was less efficiently used for DHA biosynthesis, which suggests a differential metabolism of endogenous EPA compared with exogenous EPA. However, on a per mole basis, preformed EPA was 3.6 times more effective toward DHA synthesis than was ALA. Newborns required an intake of approximate to 5 mg preformed DHA . kg(-1).d(-1) to maintain plasma DHA homeostasis. Am J Clin Nutr 2010; 92: 284-93.”
“A molecularly imprinted stir bar was prepared using bensulfuron-methyl as the template molecule and methacrylic acid as the functional monomer. The imprinted and nonimprinted stir bars were characterized by scanning electron microscopy, nitrogen sorption porosimetry, thermogravimetric analysis, and differential scanning calorimetry. Extraction time, desorption time and pH value affecting extraction efficiency of the stir bar have been evaluated to achieve the selectively direct preconcentration of the template from aqueous samples.

These findings suggest that unlike in vision and audition, in olfaction there is a systematic predictable link between stimulus PLX-4720 structure and stimulus pleasantness. This goes in contrast to the popular notion that odorant pleasantness is completely subjective, and may provide a new method for odor screening and environmental monitoring, as well as a critical building block for digital transmission of smell.”
“We manipulate the interaction of Co’s 3d and Eu’s 4f electrons to design and fabricate ZnO: Co +Eu, which possesses intrinsic ferromagnetism at ambient temperature. The results show that the Eu ions tend to neighboring

Co ions in order to eliminate the lattice distortion caused by the larger Eu ions via strain coupling. It was also revealed that the preference of parallel spin alignment between Eu and Co ions results in ferromagnetism. The theoretical

analyses and our experimental results evidenced that the induced ferromagnetism C59 Wnt price in the Eu and Co codoped ZnO is intrinsic at ambient temperature. (C) 2011 American Institute of Physics. [doi:10.1063/1.3530840]“
“P>Cirrhotic cardiomyopathy may appear following liver transplantation. Brain-natriuretic peptide (BNP) values exceeding 391 pg/ml or 567 pg/ml may partially reflect ventricular stress because of cardiac dysfunction or indicate cirrhotic cardiomyopathy, respectively. The aim of the study was to assess cardiac dysfunction in liver transplant patients and its correlation with BNP as a biomarker. From 1/2008 to 7/2009, 157 adult liver transplant recipients with proven cirrhosis were recruited for the study. BNP and liver enzymes were recorded upon admission, on the first postoperative day (POD) and 1 week after transplantation. Patients with ischemic heart attacks were excluded from the study. We identified two groups of patients. Group 1 was characterized by a BNP < 391 pg/ml and Group 2 by a BNP > 391 pg/ml. Group 2 had a significantly higher model of end-stage liver disease score than Pictilisib mouse Group 1 (median 30, range 10-40 versus median 22, range 10-40, respectively; P = 0.003), required significantly more dialysis treatments and had a significantly

higher mortality rate. Postoperative echocardiography in patients with a BNP > 391 pg/ml indicated diastolic dysfunction in all of the patients and systolic dysfunction in 10 of the patients. Increased serum-BNP was associated with an overall higher mortality rate.”
“Copy number variants (CNVs) have recently been recognized as a common form of genomic variation in humans. Hundreds of CNVs can be detected in any individual genome using genomic microarrays or whole genome sequencing technology, but their phenotypic consequences are still poorly understood. Rare CNVs have been reported as a frequent cause of neurological disorders such as mental retardation (MR), schizophrenia and autism, prompting widespread implementation of CNV screening in diagnostics.

The information provided here described the CT appearance of a laryngeal cyst and the use of CT in diagnosis and surgical planning. Congenital laryngeal cysts can be resected via a lateral submucosal approach. (J ABT-737 clinical trial Am Vet Med Assoc 2010;236:1328-1333)”
“Objectives: The (ever) prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) can vary widely depending on the definition used. We determined the prevalence of NPSLE in 1000 Faces of Lupus, a large multicenter Canadian cohort.

Methods: Adults enrolled at 10 sites who satisfied the American College of Rheumatology (ACR) classification for systemic lupus erythematosus (SLE) were included. NPSLE was defined as (i) NPSLE by ACR

classification criteria (seizures or psychosis), (ii) ACR, SLEDAI (seizure, psychosis, organic brain syndrome, selleck cranial nerve disorder, headache, and cerebrovascular accident (CVA)), SLAM (CVA, seizure, cortical dysfunction, and headache), and SLICC (cognitive impairment, psychosis, seizures, CVA, cranial or peripheral neuropathy, and transverse myelitis) with and (iii) without minor nonspecific NPSLE manifestations (including mild depression, mild cognitive impairment, and electromyogram-negative

neuropathies), and (iv) by ACR and SLEDAI neuropsychiatric (NP) indexes alone. Factors associated with NPSLE were explored using regression models.

Results: Cohort size was 1253, with mean disease 12 +/- 10 years, mean age 41 +/- 16 years, and 86% female. Subgroup size was dependent on the specific definition of NPSLE. Prevalence of NPSLE was 6.4% in group (i), n = 1253 (n = 80); 38.6% in group (ii), n = 681(n = 263); 28.7% in group (iii), n = 586 (n = 168); and 10.2% in group (iv), n = 1125 (n = 115). In univariate analysis, Aboriginals had a nearly 2-fold increase in frequency of NPSLE in all groups. Education level and income were not associated with NPSLE (P = 0.32 and 0.03, respectively). As well, number of

ACR criteria, SLAM, age at diagnosis, disease duration, PHA-739358 and gender were not associated with NPSLE. Anti-Ro was significantly associated in groups (i) and (iv) and antiphospholipid antibodies (aPL) were increased in groups (i), (ii), and (iii); however, this lost significance when thromboembolic events were excluded from SLICC, SLEDAI, and SLAM indexes. In group (iv), absence of anti-Sm was significant. In multivariate analysis, anti-Ro and aPL (i) and anti-Ro + and lack of anti-Sm (iv) were significant. NPSLE was not increased in those with + anti-DNA, La, or ribonucleoprotein (RNP), lupus anticoagulant (LAC), or anticardiolipin (aCL) antibody.

Conclusions: The prevalence and factors associated with NPSLE varied depending on the definition used, was highest in Aboriginals, and may be higher if +anti-Ro or aPL are present. SLAM and SLICC include mild subjective disease manifestations, which contributed to a 10% higher prevalence of NPSLE compared to a more strict definition.

83 mg/kg. The data obtained shows that C. lutea posseses analgesic activity that is peripherally mediated.”
“Oxidative stress is a cellular event that occurs at the molecular level and arises when the balance of intrinsic antioxidants and reactive molecular species tips towards the latter. Although oxidative KU-57788 mouse stress has been implicated in the pathophysiology of many diseases, designing therapeutic regimens to circumvent or manage these events remains elusive. In the following review, a description

of cellular redox regulation under normal and pathophysiological states will be presented. Berberine is an isoquinoline alkaloid present in various plants such as goldenseal, goldenthread, Oregon grape and barberry. Although most of these are commercialized as natural health products, barberry is commonly used in Persian and Georgian cuisines. In this review, the therapeutic potential and efficacy of berberine for the management of oxidative stress and its associated diseases will be discussed. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.”
“The study investigated the effect of anaerobically digested cow dung using polyethylene tube digester on the antimicrobial property of Aloe barbadensis,

(Aloe vera) Allium sativum (Garlic) and Zingiber officinale (Ginger). The methanol extracts of the three medicinal plants grown on soil augmented with anaerobically digested cow dung slurry exhibited marked antimicrobial activities on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Asperigillus niger and Trichophyton mentogrophyte isolated from clinical specimens. All selleck screening library the three medicinal plants grown on digested cow dung slurry exhibited greater mean zones of inhibition on all the pathogens than that grown on soil augmented with undigested cow dung and soil not augmented at all. A. sativum (Garlic) raised on digested cow dung slurry exhibited the highest mean zones of inhibitions with spore germination of the fungi totally inhibited when compared with the two other medicinal plants. The results in this study have shown that anaerobically digested cow dung

slurry does not only yield pathogen free manure, increased fertilizer and biogas but can improve the antimicrobial activity of medicinal plants.”
“The grafting of vinyl monomers is an important PF-4708671 method for replacing hydrophilic hydroxyl groups present on the surface of natural fibers by hydrophobic polymer chains. It improves the compatibility of natural fibers with polymer matrixes during the fabrication of natural-fiber-reinforced polymer composites. This article deals with the graft copolymerization of acrylonitrile onto Agave americana fibers in air in the presence of ceric ammonium nitrate as a redox initiator. A maximum percentage grafting of 24% was obtained after the optimization of various reaction parameters, including the reaction time, temperature, and concentrations of nitric acid, initiator, and monomer.

Furthermore, the timely selleck chemicals assembly and maintenance of synaptonemal complexes during early prophase I are affected in Ossgo1 mutants. Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1.”
“Cognitive dysfunction

is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate the effect of strict volume control by salt restriction and ultrafiltration on cognitive functions in HD patients. This cross-sectional study was composed of 22 HD patients who were normotensive Lazertinib mouse by applying a strict volume control, 24 HD patients who were normotensive by receiving anti-hypertensive drugs, and 20 healthy controls. The strict volume control was defined as managing of blood pressure control by strict salt restriction and insistent ultrafiltration. P300 recording as an indicator of cognitive disfunction was measured when blood pressures were reached at target level at the end of six-month follow-up period. In all patients,

dimensions of the heart were evaluated with echocardiography on an interdialytic day. The cardiothoracic ratio and echocardiographic dimensions were significantly lower in patients with strict volume control. P300 amplitudes were significantly lower in patients on antihypertensive drugs than in patients with strict volume control (9.5 +/- 5.1 versus 11.3 +/- 5.4 mu V). P300 latency was longer in patients on antihypertensive drugs than in the control group and patients with strict volume control (359.9 +/- 39.6 versus 345.6 +/- 36.7 ms). Our results suggest that hypervolemia may be one of the causal and potentially modifiable factors of cognitive dysfunction. Strict

volume control may have beneficial effects on cognitive functions in hemodialysis patients.”
“The rheokinetics of the curing process of a resol resin was studied through isothermal analysis. The resin was subjected to a curing pretreatment until gelation was reached. SC79 clinical trial Rectangular torsion was chosen as the appropriate strain form to carry out the study of the resin’s curing kinetics, because the viscoelastic behavior of the material was closer to an ideal solid than to a Newtonian fluid. Seven operating temperatures were selected for analysis (80-110 degrees C). The Arrhenius and Kiuna rheokinetic models were applied to the resin’s complex viscosity (eta*) evolution during the crosslinking of polymer. The resol resin had curing activation energies of 62.6 and 65.8 kJ/mol when the Arrhenius model was applied in four-and six-parameter forms, respectively. The Kiuna model was proposed to fit the nonlinear viscosity region found at the highest temperatures.

This study utilizes IRT to identify a reduced set of optimally performing screening indicators for the four CAM features of delirium.

Methods: Older adults were screened for enrollment in a large scale delirium study conducted in Boston-area postacute facilities (n = 4,598). Trained interviewers conducted a structured delirium assessment that culminated in rating the presence or absence of four features of delirium based on the CAM. A pool of 135 indicators from established cognitive testing and delirium assessment tools were assigned by an expert panel into two indicator sets per CAM feature representing

(a) direct interview questions, including cognitive testing, and (b) interviewer observations. We used IRT models to identify the best items to screen for each feature of delirium.

Results: We identified DMXAA 10 dimensions and chose up to five indicators per dimension. Preference was given to items with peak psychometric information in the latent trait region relevant for screening for delirium. The final set of 48 indicators, derived from

39 items, maintains fidelity to clinical constructs of delirium and maximizes psychometric information relevant for screening.

Conclusions: We identified optimal indicators from a large item pool Mocetinostat in vivo to screen for delirium. The selected indicators maintain fidelity to clinical constructs of delirium while maximizing psychometric information important for screening. This reduced item set facilitates development of short screening tools suitable for use in clinical applications or research studies. This study represents buy Acadesine the first step in the establishment of an item bank for delirium screening with potential questions for clinical researchers to select from and tailor according to their research objectives.”
“”"Essential

Oil of Thymus vulgaris: Preparation of Pharmaceutical Mouthwash Formulation and In Vitro Evaluation of the Bacterial Plaque-Inhibiting Properties”". The aim of this study was to evaluate the in vitro effect of the essential oil of Thymus vulgaris (thyme) pure or incorporate in a alcohol-free pharmaceutical mouthwash formulation, against Streptococcus mutans (ATCC 25175), being determined the Minimal Inhibitory Concentration (MIC) and the effect in the bacterial plate formation. The MIC value obtained for the essential oil was 100 mu g/mL (1 %). The mouthwash pharmaceutical formulation containing commercial essential oil of T. vulgaris was preparated. Microbiological and macroscopic analysis as well as analyses for MEV confirmed the effectiveness of this new alcohol-free mouthwash formulation containing essential oil of T. vulgaris as agent with plaque-inhibiting properties and possible application in the preventive dentistry.