S. chartarum is usually referred to as “toxic mold”; toxicity has been associated with exposure to spores and production of mycotoxins [3–5]. Chk inhibitor In addition, S. chartarum and other indoor molds have been linked to damp building-related illnesses (DBRI) such as allergic reactions of the upper respiratory system (e.g. irritated eyes, nose and throat) . Likewise, cases of idiopathic pulmonary hemosiderosis
have been associated with S. chartarum indoor exposures [7, 8]. Also, S. chartarum may trigger immunologic, neurologic, and oncogenic disorders [5, 7, 9]. Proper risk management decisions are necessary whenever S. chartarum is identified in mold-infested environments for the proper remediation of this mold and minimal exposure of occupational workers to its toxic effects [10, 11]. At present, there are no standardized protocols to identify the need for mold-remediation for indoor built environments. Most of the published mold-remediation guidelines recommend visual inspection for fungal growth as part of the assessment for mold-remediation at damp or water-damaged settings. Usually by the time visible mold growth is observed, it implies that inaccessible areas within the building construction are already mold-contaminated [11, 12]. The implementation of new technologies for close monitoring learn more of secluded, damp spaces is necessary for the early detection of mold growth. Several studies suggested
the use of microbial volatile organic compound (MVOC) profiles as a diagnostic tool to determine mold-related problems in homes and buildings [13–15]. MVOCs are volatile organic chemical emissions associated with mold metabolism and may be linked to some of the adverse respiratory conditions generated by S. chartarum[16–19]. Combinations of MVOC emissions generate characteristic odors; these are detected prior to visual mold growth in buildings where occupants complaint of poor indoor air quality [20, 21]. MVOCs are suitable markers because they easily diffuse through weak barriers
like wallpaper and small crevices [12, 15, 20]. Likewise, they could be used for early detection of mold growth in hidden cavities (i.e. air ducts) and infrequently-visited places such as attics, crawl spaces and basements [12, 22]. Several studies suggest that MVOC emission patterns could be used for the identification and Flavopiridol (Alvocidib) classification of closely related microorganisms [23, 24]. Larsen and Frisvad  analyzed the MVOCs emissions pattern of 47 Penicillium taxa and showed and the MVOCs emission profiles were unique enough to classify Penicillium to the species level. In a previous study, our laboratory characterized MVOCs emitted by three toxigenic strains of S. chartarum when grown on Sabouraud Dextrose Agar (SDA) and gypsum wallboard . In the present study, we included seven toxigenic strains of S. chartarum to identify unique MVOCs for this mold to help in the construction of a robust MVOC library.